Reference Ranges for Fetal Brain Fissure Development on 3-Dimensional Sonography in the Multiplanar Mode

Reference Ranges for Fetal Brain Fissure Development on 3-Dimensional Sonography in the Multiplanar Mode

Author Alves, Cynthia Maria Soares Autor UNIFESP Google Scholar
Araujo Junior, Edward Autor UNIFESP Google Scholar
Nardozza, Luciano Marcondes Machado Autor UNIFESP Google Scholar
Goldman, Susan Menasce Autor UNIFESP Google Scholar
Martinez, Luiz Henrique Autor UNIFESP Google Scholar
Martins, Wellington de Paula Google Scholar
Oliveira, Patricia Soares Autor UNIFESP Google Scholar
Moron, Antonio Fernandes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Black Duck Software Inc
Univ Calif Irvine
Abstract Objectives-To determine reference ranges for measurements of fetal cerebral fissures by 3-dimensional (3D) sonography in the multiplanar mode and to evaluate the reliability and concordance of these measurements.Methods-A cross-sectional study was conducted on 393 women with normal pregnancies at 22 weeks to 33 weeks 6 days. The distances between the internal bone plate of the fetal calvaria and the sylvian, parieto-occipital, hippocampal, and calcarine fissures were assessed. To obtain the distances for the first 3 fissures, a 3D sweep was made in the axial plane, at the level of the lateral ventricles. To obtain the distance for the calcarine fissure, a coronal sweep was used, at the level of the occipital lobes. To evaluate the correlation between the fissures and gestational age, polynomial regression was performed with adjustments using the coefficient of determination (R-2). Reliability was determined with intraclass correlation coefficients and concordance with concordance limits.Results-The mean distances +/- SD to the sylvian, parieto-occipital, hippocampal, and calcarine fissures were 10.42 +/- 2.28, 22.38 +/- 3.23, 24.88 +/- 4.67, and 21.19 +/- 2.73 mm, respectively. These distances correlated with gestational age such that the best fit with the linear equation produced R-2 values of 0.582, 0.627, 0.860, and 0.458 for the sylvian, parieto-occipital, hippocampal, and calcarine fissures. Reliability analyses showed intraobserver and interobserver intraclass correlation coefficients of 0.90 to 0.95 and 0.85 to 0.97. The concordance limits were-1.33 to 1.30 and -2.38 to 2.28 mm for the intraobserver evaluation and -1.60 to 2.57 and -3.51 to 2.73 mm for the interobserver evaluation.Conclusions-Cerebral fissures can be measured by 3D sonography at 22 to 33 weeks of pregnancy with acceptable reliability and concordance. Reference ranges for this gestational period have thus been described.
Keywords fetal brain
fissures
reference ranges
reproducibility
3-dimensional sonography
Language English
Date 2013-02-01
Published in Journal Of Ultrasound In Medicine. Laurel: Amer Inst Ultrasound Medicine, v. 32, n. 2, p. 269-277, 2013.
ISSN 0278-4297 (Sherpa/Romeo, impact factor)
Publisher Amer Inst Ultrasound Medicine
Extent 772-796
Origin http://dx.doi.org/10.7863/jum.2013.32.2.269
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000330905200008
URI http://repositorio.unifesp.br/11600/44779

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