Role of the caudal pressor area in the regulation of sympathetic vasomotor tone

Role of the caudal pressor area in the regulation of sympathetic vasomotor tone

Autor Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Carillo, Bruno de Arruda Autor UNIFESP Google Scholar
Oliveira-Sales, Elizabeth Barbosa de Autor UNIFESP Google Scholar
Silva, Adilson Marques da Autor UNIFESP Google Scholar
Silva, Nyam Florencio da Google Scholar
Futuro Neto, Henrique Azevedo Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Espírito Santo Laboratório de Neuromorfologia
Universidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências Fisiológicas
Santa Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de Ciências
Resumo It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.
Palavra-chave Rostral ventrolateral medulla
Rat
Glutamate
Blood pressure
Caudal pressor area
Sympathetic vasomotor tone
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2008-07-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 557-562
Fonte http://dx.doi.org/10.1590/S0100-879X2008000700002
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000259326100002
SciELO S0100-879X2008000700002 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4465

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