Risk factors for death in children and adolescents with cancer and sepsis/septic shock

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dc.contributor.author Silva, Elenice Domingos da [UNIFESP]
dc.contributor.author Koch Nogueira, Paulo Cesar [UNIFESP]
dc.contributor.author Russo Zamataro, Tania Maria [UNIFESP]
dc.contributor.author Carvalho, Werther Brunow de [UNIFESP]
dc.contributor.author Petrilli, Antonio Sergio [UNIFESP]
dc.date.accessioned 2018-06-15T18:07:35Z
dc.date.available 2018-06-15T18:07:35Z
dc.date.issued 2008-07-01
dc.identifier http://dx.doi.org/10.1097/MPH.0b013e31815acae0
dc.identifier.citation Journal Of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 30, n. 7, p. 513-518, 2008.
dc.identifier.issn 1077-4114
dc.identifier.uri http://repositorio.unifesp.br/11600/44550
dc.description.abstract Objective: To assess risk factors for mortality in children and adolescents with cancer and sepsis/septic shock, admitted to intensive care unit.Patients and Methods: Retrospective Study of a cohort of cancer and sepsis/septic shock patients (n = 155) admitted to Oncological Pediatric Intensive Care Unit, between October 1998 and October 2001, with assessment of 12 potential risk factors for mortality by univariate analysis, followed by multivariable analysis.Results: Forty-seven out of 155 patients died (30.3%). In the present sample, after multivariable analysis, 3/12 variables proved to be statistically significant: respiratory infection [hazard ratio (HR) = 2.3 and 95% confidence interval (Cl) = 1.3-4.2], duration of granUlocytopenia (HR = 2.4 and 95% Cl = 1.2-4.9), and number of organ dysfunction (HR = 7.4 and 95% Cl = 2.6-21.3).Conclusions: Our data suggest that mortality in Oncological Pediatric Intensive Care Unit is high and the main factors involved in prognosis are number of dysfunctional organs, respiratory infections, and duration of granulocytopenia; the mortality rises 7.4 times for each dysfunctional organ. We believe that prospective and multicenter Studies are necessary to better characterize risk factors that are specific for cancer patients to produce a particular score to predict severity of complications and mortality of children with cancer. en
dc.format.extent 513-518
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Journal Of Pediatric Hematology Oncology
dc.rights Acesso restrito
dc.subject mortality en
dc.subject sepsis en
dc.subject child en
dc.subject cancer en
dc.subject critical care en
dc.title Risk factors for death in children and adolescents with cancer and sepsis/septic shock en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, GRAACC, Inst Oncol Pediat, Oncol Pediat Intens Care Unit, BR-04023062 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Pediat, BR-04023062 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Pediat Intens Care Unit, BR-04023062 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, IOP, GRAACC, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, GRAACC, Inst Oncol Pediat, Oncol Pediat Intens Care Unit, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Pediat, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Pediat Intens Care Unit, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, IOP, GRAACC, BR-04023062 Sao Paulo, Brazil
dc.identifier.doi 10.1097/MPH.0b013e31815acae0
dc.description.source Web of Science
dc.identifier.wos WOS:000257591800005



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