Leptin assessment in acute lymphocytic leukemia survivors: Role of cranial radiotherapy?

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dc.contributor.author Siviero-Miachon, Adriana Aparecida [UNIFESP]
dc.contributor.author Spinola-Castro, Angela Maria [UNIFESP]
dc.contributor.author Tosta-Hernandez, Patricia Debora Cavalcanti [UNIFESP]
dc.contributor.author Lee, Maria Lucia de Martino
dc.contributor.author Petrilli, Antonio Sergio
dc.date.accessioned 2018-06-15T18:07:34Z
dc.date.available 2018-06-15T18:07:34Z
dc.date.issued 2007-11-01
dc.identifier http://dx.doi.org/10.1097/MPH.0b013e318159a545
dc.identifier.citation Journal Of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 29, n. 11, p. 776-782, 2007.
dc.identifier.issn 1077-4114
dc.identifier.uri http://repositorio.unifesp.br/11600/44549
dc.description.abstract Leptin has been hypothesized to play a role in the development of obesity in leukemia survivors, particularly those who have received cranial radiotherapy. This cross-sectional study evaluated the relationship between leptin levels and body mass index (BMI) in a sample of 26 acute lymphocytic leukemia survivors of both sexes, treated with and without cranial irradiation, aged 7.6 to 17 years, at a mean 3.4 +/- 2.0 years off treatment. There were significantly more males among the irradiated group (P < 0.001), even though no differences were encountered in pubertal stage (P = 1.000), BMI standard deviation score (mean SD) (0.68 +/- 1.00 vs. 1.19 +/- 0.78; P = 0.164), or leptin concentrations (17.01 +/- 17.04 vs. 23.3 +/- 13.4; P = 0.309). Nonetheless, there was a positive correlation between the natural logarithm of leptin and BMI standard deviation score [t(22) = 2.348, P = 0.028], however, no differences were recorded among irradiated and nonirradiated patients [F(2,22) = 0.384, P = 0.685]. When this relationship was compared between sexes, a significant difference was encountered [F(2,22) = 4.907, P 0.017], with males having the strongest association (R-males(2) = 65.5%, R-females(2) = 34.7% ).Leptin is a reliable adiposity index as it strongly correlates with BMI. Overall, the current data suggest that cranial irradiation did not play a role upon this relationship; however, sex differences influenced positively this correlation. en
dc.format.extent 776-782
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Journal Of Pediatric Hematology Oncology
dc.rights Acesso restrito
dc.subject leptin en
dc.subject anthropometry en
dc.subject body weight en
dc.subject leukemia en
dc.subject lymphocytic en
dc.subject acute/radiotherapy and leukemia en
dc.subject acute/drug therapy en
dc.title Leptin assessment in acute lymphocytic leukemia survivors: Role of cranial radiotherapy? en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, EPM, Div Pediat Endocrinol, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, EPM, Pediat Oncol Inst, GRAACC, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, EPM, Div Pediat Endocrinol, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, EPM, Pediat Oncol Inst, GRAACC, Sao Paulo, Brazil
dc.identifier.doi 10.1097/MPH.0b013e318159a545
dc.description.source Web of Science
dc.identifier.wos WOS:000251077300012



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