Author |
Siviero-Miachon, Adriana Aparecida
![]() ![]() Spinola-Castro, Angela Maria ![]() ![]() Tosta-Hernandez, Patricia Debora Cavalcanti ![]() ![]() Lee, Maria Lucia de Martino ![]() Petrilli, Antonio Sergio ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) |
Abstract | Leptin has been hypothesized to play a role in the development of obesity in leukemia survivors, particularly those who have received cranial radiotherapy. This cross-sectional study evaluated the relationship between leptin levels and body mass index (BMI) in a sample of 26 acute lymphocytic leukemia survivors of both sexes, treated with and without cranial irradiation, aged 7.6 to 17 years, at a mean 3.4 +/- 2.0 years off treatment. There were significantly more males among the irradiated group (P < 0.001), even though no differences were encountered in pubertal stage (P = 1.000), BMI standard deviation score (mean SD) (0.68 +/- 1.00 vs. 1.19 +/- 0.78; P = 0.164), or leptin concentrations (17.01 +/- 17.04 vs. 23.3 +/- 13.4; P = 0.309). Nonetheless, there was a positive correlation between the natural logarithm of leptin and BMI standard deviation score [t(22) = 2.348, P = 0.028], however, no differences were recorded among irradiated and nonirradiated patients [F(2,22) = 0.384, P = 0.685]. When this relationship was compared between sexes, a significant difference was encountered [F(2,22) = 4.907, P 0.017], with males having the strongest association (R-males(2) = 65.5%, R-females(2) = 34.7% ).Leptin is a reliable adiposity index as it strongly correlates with BMI. Overall, the current data suggest that cranial irradiation did not play a role upon this relationship; however, sex differences influenced positively this correlation. |
Keywords |
leptin
anthropometry body weight leukemia lymphocytic acute/radiotherapy and leukemia acute/drug therapy |
Language | English |
Date | 2007-11-01 |
Published in | Journal Of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 29, n. 11, p. 776-782, 2007. |
ISSN | 1077-4114 (Sherpa/Romeo, impact factor) |
Publisher | Lippincott Williams & Wilkins |
Extent | 776-782 |
Origin |
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Access rights | Closed access |
Type | Article |
Web of Science ID | WOS:000251077300012 |
URI | http://repositorio.unifesp.br/11600/44549 |
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