Transdermal estradiol priming during clonidine stimulation test in non-growth hormone deficient children with short stature: A pilot study

Transdermal estradiol priming during clonidine stimulation test in non-growth hormone deficient children with short stature: A pilot study

Author Borghi, MMS Google Scholar
Longui, C. A. Google Scholar
Calliari, L. E. Google Scholar
Faria, CDC Google Scholar
Kochi, C. Google Scholar
Monte, O. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The diagnosis of growth hormone (GH) deficiency is strongly influenced by age, body mass index and presence of gonadal steroids. Priming with oral estradiol (E-2) is one possible way to overcome the impact of variable levels of sex steroids. We describe the effects of transdermal estradiol (E-2-t) priming on GH response after clonidine stimulation. in prepubertal children with familial short stature (group 1, n = 12) or constitutional growth delay (group 2, n = 22). All patients underwent A clonidine test (0.1 mg/m(2), p.o.) followed by a clonidine plus E-2-t test (50 mu g/day) with a 7-day interval. Before E-2-t, basal GH and insulin-like growth factor-I (IGF-I) values were similar in the two groups. After E-2-t priming, basal GH was significantly higher only in group 2. When compared with group 1, patients from group 2 had a significant increase of GH peak response when submitted to E-2-t. The number of patients in both groups with adequate GH peak response was higher after E-2-t priming. We conclude that E-2-t priming is able to increase GH peak response after clonidine stimulation and also improves the accuracy of the clonidine test in the diagnosis of GH deficiency. Compared to oral administration, E-2-t delivery can prevent liver toxicity, providing a more physiological mechanism of GH secretion.
Keywords growth hormone deficiency
clonidine test
transdermal estradiol
IGF-I
short stature
Language English
Date 2006-03-01
Published in Journal Of Pediatric Endocrinology & Metabolism. Tel Aviv: Freund Publishing House Ltd, v. 19, n. 3, p. 223-227, 2006.
ISSN 0334-018X (Sherpa/Romeo, impact factor)
Publisher Freund Publishing House Ltd
Extent 223-227
Origin http://dx.doi.org/10.1515/JPEM.2006.19.3.223
Access rights Closed access
Type Article
Web of Science ID WOS:000236479400006
URI http://repositorio.unifesp.br/11600/44539

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