Impairment in Anthropometric Parameters and Body Composition in Females with Classical 21-Hydroxylase Deficiency

Impairment in Anthropometric Parameters and Body Composition in Females with Classical 21-Hydroxylase Deficiency

Author Goncalves, Ezequiel Moreira Google Scholar
Valente de Lemos-Marini, Sofia Helena Google Scholar
Mello, Maricilda Palandi de Google Scholar
Matias Baptista, Maria Tereza Google Scholar
Rodrigues D'Souza-Li, Lilia Freire Google Scholar
Baldin, Alexandre Duarte Google Scholar
Gomes Carvalho, Wellington Roberto Google Scholar
Farias, Edson Santos Google Scholar
Guerra-Junior, Gil Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract The aim of this study was to evaluate the physical measurements and body composition of female patients with the classic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Twenty-eight girls with CAH were classified according to both hormonal control (well or not well controlled) and the clinical form of the disease (simple virilizing or salt-wasting). In the control group, 112 healthy individuals were included, divided into two subgroups (male and female). Both patients and controls were subdivided by age into three groups according to pubertal stage: <= 10 years (prepubertal), 11-15 years (pubertal), and >= 15 years (postpubertal). Anthropometrical evaluations and bioelectrical impedance were used to obtain the physical measurement and body composition data. The patients with the simple virilizing form presented higher values for BMI, waist, arm fat area, and fat mass percentage. The not well controlled group presented shorter leg length. Values obtained for BMI as well as for arm fat area, brachial circumference, waist, hip, bi-iliac diameter and fat mass percentage were significantly higher in the patients than in the controls, whereas leg length, hand size and the percentages of water and lean mass were lower. Alterations in body composition were observed in all age groups, mainly by increase of fat mass with age. After puberty, impairments in limb measurements (leg, hand and foot) were more evident. Patients with CAH presented differences in anthropometric parameters but mainly in body composition. Hence, more comprehensive and careful anthropometric evaluation during monitoring of patients with CAH is recommended.
Keywords anthropometry
body composition
congenital adrenal hyperplasia
bioelectric impedance
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2009-06-01
Published in Journal Of Pediatric Endocrinology & Metabolism. Berlin: Walter De Gruyter Gmbh, v. 22, n. 6, p. 519-529, 2009.
ISSN 0334-018X (Sherpa/Romeo, impact factor)
Publisher Walter De Gruyter Gmbh
Extent 519-529
Access rights Closed access
Type Article
Web of Science ID WOS:000267771700008

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