Assessment of Nutritional Status: Vitamin A and Zinc in Patients With Common Variable Immunodeficiency

Assessment of Nutritional Status: Vitamin A and Zinc in Patients With Common Variable Immunodeficiency

Author Calheiro dos Santos-Valente, E. Autor UNIFESP Google Scholar
Silva, R. da Autor UNIFESP Google Scholar
Moraes-Pinto, M. I. de Autor UNIFESP Google Scholar
Oselka Saccardo Sarni, R. Autor UNIFESP Google Scholar
Costa-Carvalho, B. T. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Alfenas
ABC Univ
Abstract Background: Patients with common variable immunodeficiency (CVID) present with low antibody levels, impaired lymphocyte function, and chronic inflammation. Vitamin A and zinc are essential components of the immune system and can be redistributed in the body as a result of inflammation.Objective: To compare levels of retinol, beta-carotene, and zinc in patients with CVID and healthy controls after evaluating a series of parameters for each participant.Patients and Methods: We performed a cross-sectional study of CVID patients and healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising a complete blood count and determination of levels of C-reactive protein (CRP), lipopolysaccharide (LPS), soluble CD14 (sCD14), retinol, beta-carotene, and serum and erythrocyte zinc.Results: We included 17 patients (mean age, 28.54 years) and 17 controls. Mean (SD) retinol levels were lower in patients: 1.99 (0.67) mu mol/L vs 2.72 (0.96) mu mol/L. Median beta-carotene levels were similar in both groups (0.30 mu mol/L). Median serum zinc levels were 50.0 mu g/dL (50-100 mu g/dL) in the patients and 100.0 mu g/dL (50-150 mu g/dL) in the controls. Mean levels of erythrocyte zinc were lower among patients: 37.32 (10.51) mu gZn/gHb vs 44.91 (7.67) mu gZn/gHb in the controls. Median CRP levels were significantly higher among patients: 4.99 (0.15-34.51) mg/L vs 0.55 (0.17-6.06) mg/L. No differences in translocation marker levels were observed between the groups.Conclusions: CVID patients had lower levels of retinol and zinc than controls. Since micronutrient deficiency could aggravate their disease and contribute to chronic inflammation, micronutrient status should always be assessed in patients with primary immunodeficiency.
Keywords Antibody deficiency
Vitamin A
Bacterial translocation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 10109-1/2008
Date 2012-01-01
Published in Journal Of Investigational Allergology And Clinical Immunology. Barcelona: Esmon Publicidad S A, v. 22, n. 6, p. 427-431, 2012.
ISSN 1018-9068 (Sherpa/Romeo, impact factor)
Publisher Esmon Publicidad S A
Extent 427-431
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000311471100006

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