Efficacy of celecoxib in treating symptoms of viral pharyngitis: A double-blind, randomized study of celecoxib versus diclofenac

Efficacy of celecoxib in treating symptoms of viral pharyngitis: A double-blind, randomized study of celecoxib versus diclofenac

Autor Weckx, LLM Google Scholar
Ruiz, J. E. Google Scholar
Duperly, J. Google Scholar
Mendizabal, GAM Google Scholar
Rausis, MBG Google Scholar
Piltcher, S. L. Google Scholar
Saffer, M. Google Scholar
Matsuyama, C. Google Scholar
Levy, S. Google Scholar
Fort, J. G. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Familia
GPPG
Complexo Hosp Santa Casa Porto Alegre
Hosp CEMA
Resumo This study compared the efficacy and safety of the cyclooxygenase-2 specific inhibitor celecoxib with the conventional nonsteroidal anti-inflammatory drug diclofenac in the symptomatic treatment of viral pharyngitis. Adult patients from 27 study centers in Latin America were treated with oral doses of celecoxib 200 mg once daily or 200 mg twice daily, or diclofenac 75 mg twice daily for 5 days in a double-blind, randomized study. The primary efficacy assessment was 'Throat Pain on Swallowing' on day 3. In addition, secondary quality-of-life assessments were performed on days 3 and S. All adverse events and treatment-emergent signs and symptoms were recorded. Data from 313 patients were evaluable for efficacy (105 celecoxib 200 mg once daily, 107 celecoxib 200 mg twice daily, 101 diclofenac 75 mg twice daily). The upper 95% confidence limits for the visual analog scale of 'Throat Pain on Swallowing' on day 3 for celecoxib 200 mg once daily relative to diclofenac 75 mg twice daily, and celecoxib 200 mg twice daily relative to diclofenac 75 mg twice daily were 9.26 and 7.83, respectively. All secondary efficacy and quality-of-life measures were clinically similar for the three treatment groups, and no statistically significant differences were detected. The incidences of treatment-emergent adverse events and withdrawals due to adverse events were similar for all groups, but numerically higher among patients taking diclofenac than celecoxib. More patients in the diclofenac group reported gastrointestinal complaints (7.3%) compared with those in the celecoxib groups (4.3% in the celecoxib 200 mg once-daily group and 3.4% in the celecoxib 200 mg twice-daily group). In conclusion, 5 days of treatment with celecoxib 200 mg once daily is as effective as diclofenac 75 mg twice daily in the symptomatic treatment of viral pharyngitis. Celecoxib 200 mg once daily is also as effective as celecoxib 200 mg twice daily in this condition.
Assunto celecoxib
cyclooxygenase (COX)-2 specific inhibitors
viral pharyngitis
symptomatic treatment
throat pain on swallowing
Idioma Inglês
Data 2002-03-01
Publicado em Journal Of International Medical Research. Worthing: Cambridge Med Publ, v. 30, n. 2, p. 185-194, 2002.
ISSN 0300-0605 (Sherpa/Romeo, fator de impacto)
Editor Cambridge Med Publ
Extensão 185-194
Fonte http://dx.doi.org/10.1177/147323000203000212
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000175403900012
URI http://repositorio.unifesp.br/11600/44437

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