Enteropathogens Associated with Acute Diarrheal Disease in Urban Infants in São Paulo, Brazil

Enteropathogens Associated with Acute Diarrheal Disease in Urban Infants in São Paulo, Brazil

Author Gomes, Tania AT Google Scholar
Rassi, Vilma Google Scholar
Macdonald, Kristine L. Google Scholar
Ramos, Sonia RT Silva Google Scholar
Trabulsi, Luiz Rachid Autor UNIFESP Google Scholar
Vieira, Monica AM Google Scholar
Guth, Beatriz Ernestina Cabilio Autor UNIFESP Google Scholar
Candeias, José AN Google Scholar
Ivey, C. Google Scholar
Toledo, Maria Regina Fernandes de Autor UNIFESP Google Scholar
Blake, Paul A. Google Scholar
Institution HOSP INFANTIL MENINO JESUS
Universidade de São Paulo (USP)
CTR DIS CONTROL
Universidade Federal de São Paulo (UNIFESP)
Abstract To determine the prevalence and epidemiology of enteropathogens in acute infantile diarrhea, 500 infants less-than-or-equal-to 12 months of age with diarrhea and 500 age-matched control subjects coming to a Sao Paulo emergency room were studied. Enteropathogens were identified in 55% of case infants and 10% of controls; enteropathogenic Escherichia coli (EPEC) of classic EPEC serotypes producing EPEC adherence factor (EAF) (26% of case infants), rotavirus (14%), Salmonella species (8%), enterotoxigenic E. coli (7%), and Shigella species (5%) were associated with diarrhea. Isolation of EAF+ classic EPEC decreased with increasing age of cases and peaked in spring, whereas rotavirus was least common in early infancy and peaked in fall and winter. Bloody stool had a 36% positive predictive value for Shigella infection. EAF+ classic EPEC were highly resistant to antimicrobial drugs. Among poor Sao Paulo infants, EAF+ classic EPEC equaled or exceeded rotavirus throughout the year as a cause of diarrhea bringing children to medical attention.
Language English
Date 1991-08-01
Published in Journal Of Infectious Diseases. Chicago: Univ Chicago Press, v. 164, n. 2, p. 331-337, 1991.
ISSN 0022-1899 (Sherpa/Romeo, impact factor)
Publisher Univ Chicago Press
Extent 331-337
Origin http://dx.doi.org/10.1093/infdis/164.2.331
Access rights Closed access
Type Article
Web of Science ID WOS:A1991FY10000015
URI http://repositorio.unifesp.br/11600/44429

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