Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment

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dc.contributor.author Belnoue, Elodie
dc.contributor.author Costa, Fabio TM
dc.contributor.author Frankenberg, Tobias
dc.contributor.author Vigario, Ana Margarida
dc.contributor.author Voza, Tatiana
dc.contributor.author Leroy, Nicolas
dc.contributor.author Rodrigues, Mauricio Martins [UNIFESP]
dc.contributor.author Landau, Irène
dc.contributor.author Snounou, Georges
dc.contributor.author Renia, Laurent
dc.date.accessioned 2018-06-15T18:02:27Z
dc.date.available 2018-06-15T18:02:27Z
dc.date.issued 2004-02-15
dc.identifier http://dx.doi.org/10.4049/jimmunol.172.4.2487
dc.identifier.citation Journal Of Immunology. Bethesda: Amer Assoc Immunologists, v. 172, n. 4, p. 2487-2495, 2004.
dc.identifier.issn 0022-1767
dc.identifier.uri http://repositorio.unifesp.br/11600/44416
dc.description.abstract In this study we present the first systematic analysis of the immunity induced by normal Plasmodium yoelii sporozoites in mice. Immunization With sporozoites, which was conducted under chloroquine treatment to minimize the influence of blood stage parasites, induced a strong protection against a subsequent sporozoite and, to a lesser extent, against infected RBC challenges. The protection induced by this immunization protocol proved to be very effective. Induction of this protective immunity depended on the presence of liver stage parasites, as primaquine treatment concurrent with sporozoite immunization abrogated protection. Protection was not found to be mediated by the Abs elicited against pre-erythrocytic and blood stage parasites, as demonstrated by inhibition assays of sporozoite penetration or development in vitro and in vivo assays of sporozoite infectivity or blood stage parasite development. CD4(+) and CD8(+) T cells were, however, responsible for the protection through the induction of IFN-gamma and NO. The Journal of Immunology, 2004, 172: 2487-2495. en
dc.format.extent 2487-2495
dc.language.iso eng
dc.publisher Amer Assoc Immunologists
dc.relation.ispartof Journal Of Immunology
dc.rights Acesso restrito
dc.title Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment en
dc.type Artigo
dc.contributor.institution Univ Paris 05
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Museum Natl Hist Nat
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Inst Pasteur
dc.description.affiliation Univ Paris 05, Inst Cochin,Hop Cochin, Dept Immunol,INSERM, Unite 567,CNRS, F-75014 Paris, France
dc.description.affiliation Univ Estadual Campinas, Dept Parasitol, Campinas, Brazil
dc.description.affiliation Museum Natl Hist Nat, F-75231 Paris, France
dc.description.affiliation Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliation Inst Pasteur, Unite Parasitol Biomed, Paris, France
dc.description.affiliation Inst Pasteur, CNRS, Paris, France
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.identifier.doi 10.4049/jimmunol.172.4.2487
dc.description.source Web of Science
dc.identifier.wos WOS:000188788600062



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