Dexamethasone does not increase IGF-I and IGFBP-3 levels in man in the absence of endogenous GH

Dexamethasone does not increase IGF-I and IGFBP-3 levels in man in the absence of endogenous GH

Author Finamor, Francisco Estivallet Autor UNIFESP Google Scholar
Lengyel, AMJ Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract It has been previously shown that short-term glucocorticoid administration increases circulating IGF-I and IGFBP-3 levels both in men and rats. An increase in endogenous GH secretion or a direct hepatic effect have been suggested as possible mechanisms. The aim of this study was to investigate the effect of short-term dexamethasone administration (3 ring orally during 7 days) in 8 patients with Sheehan's syndrome in replacement therapy. All patients had GH values <2.5 mug/l after clonidine administration. Before treatment IGF-I values were 9.3 +/-3.6 mug/l (mean +/- SE) and IGFBP-3 levels were 1195 +/- 208 mug/l. After dexamethasone administration there were no significant changes either in IGF-I or IGFBP-3 values (10.7 +/-4.1 and 1110 +/- 214 mug/l, respectively). A significant increase in insulin values was observed after dexamethasone administration (before: 120 +/- 10 pmol/l; after: 175 +/- 27 pmol/l; p <0.05), while glucose levels did not reach statistical significance (before: 4.6 +/-0.3 mmol/l; after: 5.9 +/-1.0 mmol/l). Our data suggest that dexamethasone is unable to increase circulating IGF-I and IGFBP-3 levels in man in the absence of endogenous GH. (C) 2001, Editrice Kurtis.
Keywords dexamethasone
IGF-1
IGFBP-3
Sheehan's syndrome
Language English
Date 2001-12-01
Published in Journal Of Endocrinological Investigation. Milan: Editrice Kurtis S R L, v. 24, n. 11, p. 871-875, 2001.
ISSN 0391-4097 (Sherpa/Romeo, impact factor)
Publisher Editrice Kurtis S R L
Extent 871-875
Origin http://dx.doi.org/10.1007/BF03343944
Access rights Closed access
Type Article
Web of Science ID WOS:000172823600006
URI http://repositorio.unifesp.br/11600/44349

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