Effects of COX-2 inhibitor in temporomandibular joint acute inflammation

Effects of COX-2 inhibitor in temporomandibular joint acute inflammation

Author Schutz, T. C. B. Google Scholar
Andersen, M. L. Google Scholar
Tufik, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Since it is recognized that cyclo-oxygenase-2 mediates nociception and the sleep-wake cycle as well, and that acute inflammation of the temporomandibular joint ( TMJ) results in sleep disturbances, we hypothesized that cyclooxygenase-2 inhibitor would restore the sleep pattern in this inflammatory rat model. First, sleep was monitored after the injection of Freund's adjuvant ( FA group) or saline ( SHAM group) into the rats' temporomandibular joint. Second, etoricoxib was co-administered in these groups. The Freund's adjuvant group showed a reduction in sleep efficiency, in rapid eye movement ( REM), and in non-REM sleep, and an increase in sleep and REM sleep latency when compared with the SHAM group, while etoricoxib substantially increased sleep quality in the Freund's adjuvant group. These parameters returned progressively to those found in the SHAM group. Etoricoxib improved the sleep parameters, suggesting the involvement of the cyclo-oxygenase-2 enzyme in acute inflammation of the TMJ, specifically in REM sleep.
Keywords temporomandibular joint
sleep
cyclo-oxygenase-2
rat
Language English
Date 2007-05-01
Published in Journal Of Dental Research. Alexandria: Int Amer Assoc Dental Researchi A D R/a A D R, v. 86, n. 5, p. 475-479, 2007.
ISSN 0022-0345 (Sherpa/Romeo, impact factor)
Publisher Int Amer Assoc Dental Researchi A D R/a A D R
Extent 475-479
Origin http://dx.doi.org/10.1177/154405910708600516
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000245913700016
URI http://repositorio.unifesp.br/11600/44343

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