Abdominal Obesity Is Associated With Potassium Depletion and Changes in Glucose Homeostasis During Diuretic Therapy

Abdominal Obesity Is Associated With Potassium Depletion and Changes in Glucose Homeostasis During Diuretic Therapy

Author Mariosa, Lydia Sebba Souza Autor UNIFESP Google Scholar
Ribeiro Filho, Fernando Flexa Autor UNIFESP Google Scholar
Batista, Marcelo Costa Autor UNIFESP Google Scholar
Hirota, Andrea Harumi Autor UNIFESP Google Scholar
Borges, Rodolfo Leão Autor UNIFESP Google Scholar
Ribeiro, Artur Beltrame Autor UNIFESP Google Scholar
Zanella, Maria Teresa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The activation of the renin-angiotensin system (RAS) is an important mechanism that contributes to hypertension in obese individuals. Thiazide diuretics also activate the RAS in response to volume contraction and can lead to a decrease in serum potassium values and glucose metabolism abnormalities. To evaluate the impact of abdominal obesity on potassium depletion and glucose homeostasis in hypertensive patients receiving thiazide therapy, the authors studied 329 hypertensive patients without known diabetes or impaired renal function. Patients were stratified into 2 major groups according to whether they used thiazide diuretic therapy, and each group was further divided in 2 subgroups according to the presence of abdominal obesity. The authors demonstrated that obese patients receiving diuretic therapy bad lower plasma potassium levels and higher glucose values compared with nonobese patients receiving diuretic therapy. In conclusion, abdominal obesity predisposes to potassium depletion during diuretic therapy in association with effects on glucose homeostasis. J Clin Hypertens (Greenwich). 2008;10:443-449. (C) 2008 Le Jacq
Language English
Date 2008-06-01
Published in Journal Of Clinical Hypertension. Malden: Wiley-blackwell Publishing, Inc, v. 10, n. 6, p. 443-449, 2008.
ISSN 1524-6175 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 443-449
Origin http://dx.doi.org/10.1111/j.1751-7176.2008.07817.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000261099800005
URI http://repositorio.unifesp.br/11600/44266

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