LONG-LASTING EFFECTS OF CHRONIC ETHANOL ADMINISTRATION ON THE ACTIVITY OF ANTIOXIDANT ENZYMES

LONG-LASTING EFFECTS OF CHRONIC ETHANOL ADMINISTRATION ON THE ACTIVITY OF ANTIOXIDANT ENZYMES

Autor D'Almeida, Vania Autor UNIFESP Google Scholar
Monteiro, Maristela Goldnadel Autor UNIFESP Google Scholar
Oliveira, MGM Google Scholar
Pomarico, Ana Cristina Autor UNIFESP Google Scholar
Bueno, Orlando Francisco Amodeo Autor UNIFESP Google Scholar
Fernandes, M. E. da Silva Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The aim of this study was to investigate the long-lasting effects of prolonged administration of ethanol doses on oxidative processes of aged rats. We determined the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in erythrocytes of rats 15, 20, and 24 months old treated with an average daily dose of 1.5 g/Kg of ethanol or saline administered intraperitoneally for 13 weeks and after a 2 month period of withdrawal from treatment. The activity of all three enzymes decreased significantly with aging in the controls, while no age-related changes were found among treated rats. These findings are important since they are the first to show a long-lasting toxic effect of low ethanol doses observed in association with the aging process.
Assunto ALCOHOL
AGING
ANTIOXIDANT ENZYMES
LONG-LASTING EFFECT
Idioma Inglês
Data 1994-06-01
Publicado em Journal Of Biochemical Toxicology. Deerfield Beach: Vch Publishers Inc, v. 9, n. 3, p. 141-143, 1994.
ISSN 0887-2082 (Sherpa/Romeo, fator de impacto)
Editor Vch Publishers Inc
Extensão 141-143
Fonte http://doi.org/10.1002/jbt.2570090305
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994NZ72600004
URI http://repositorio.unifesp.br/11600/44191

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