LONG-LASTING EFFECTS OF CHRONIC ETHANOL ADMINISTRATION ON THE ACTIVITY OF ANTIOXIDANT ENZYMES

LONG-LASTING EFFECTS OF CHRONIC ETHANOL ADMINISTRATION ON THE ACTIVITY OF ANTIOXIDANT ENZYMES

Author D'Almeida, Vania Autor UNIFESP Google Scholar
Monteiro, Maristela Goldnadel Autor UNIFESP Google Scholar
Oliveira, MGM Google Scholar
Pomarico, Ana Cristina Autor UNIFESP Google Scholar
Bueno, Orlando Francisco Amodeo Autor UNIFESP Google Scholar
Fernandes, M. E. da Silva Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to investigate the long-lasting effects of prolonged administration of ethanol doses on oxidative processes of aged rats. We determined the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in erythrocytes of rats 15, 20, and 24 months old treated with an average daily dose of 1.5 g/Kg of ethanol or saline administered intraperitoneally for 13 weeks and after a 2 month period of withdrawal from treatment. The activity of all three enzymes decreased significantly with aging in the controls, while no age-related changes were found among treated rats. These findings are important since they are the first to show a long-lasting toxic effect of low ethanol doses observed in association with the aging process.
Keywords ALCOHOL
AGING
ANTIOXIDANT ENZYMES
LONG-LASTING EFFECT
Language English
Date 1994-06-01
Published in Journal Of Biochemical Toxicology. Deerfield Beach: Vch Publishers Inc, v. 9, n. 3, p. 141-143, 1994.
ISSN 0887-2082 (Sherpa/Romeo, impact factor)
Publisher Vch Publishers Inc
Extent 141-143
Origin http://doi.org/10.1002/jbt.2570090305
Access rights Closed access
Type Article
Web of Science ID WOS:A1994NZ72600004
URI http://repositorio.unifesp.br/11600/44191

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