Euterpe Oleracea (Acai) Modifies Sterol Metabolism and Attenuates Experimentally-Induced Atherosclerosis

Euterpe Oleracea (Acai) Modifies Sterol Metabolism and Attenuates Experimentally-Induced Atherosclerosis

Author Feio, Claudine Maria Alves Autor UNIFESP Google Scholar
Izar, Maria Cristina de Oliveira Autor UNIFESP Google Scholar
Ihara, Silvia Saiuli Miki Autor UNIFESP Google Scholar
Kasmas, Soraia Hani Autor UNIFESP Google Scholar
Martins, Celma Muniz Autor UNIFESP Google Scholar
Feio, Max N. Google Scholar
Maues, Luis A. Google Scholar
Borges, Ney C. Google Scholar
Moreno, Ronilson Agnaldo Google Scholar
Póvoa, Rui Manuel dos Santos [UNIFESP Google Scholar
Fonseca, Francisco Antonio Helfenstein Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Synchrophar
Abstract Aim: Euterpe oleracea (acai) is a fruit from the Amazon region whose chemical composition may be beneficial for individuals with atherosclerosis. We hypothesized that consumption of Euterpe oleracea would reduce atherosclerosis development by decreasing cholesterol absorption and synthesis.Methods: Male New Zealand rabbits were fed a cholesterol-enriched diet (0.5%) for 12 weeks, when they were randomized to receive Euterpe oleracea extract (n=15) or water (n=12) plus a 0.05% cholesterol-enriched diet for an additional 12 weeks. Plasma phytosterols and desmosterol were determined by ultra-performance liquid chromatography and mass spectrometry. Atherosclerotic lesions were estimated by computerized planimetry and histomorphometry.Results: At sacrifice, animals treated with Euterpe oleracea had lower levels of total cholesterol (p=0.03), non-HDL-cholesterol (p=0.03) and triglycerides (p=0.02) than controls. These animals had smaller atherosclerotic plaque area in their aortas (p=0.001) and a smaller intima/media ratio (p=0.002) than controls, without differences in plaque composition. At the end of the study, campesterol, beta-sitosterol, and desmosterol plasma levels did not differ between groups; however, animals treated with Euterpe oleracea showed lower desmosterol/campesterol (p=0.026) and desmosterol/beta-sitosterol (p=0.006) ratios than controls.Conclusions: Consumption of Euterpe oleracea extract markedly improved the lipid profile and attenuated atherosclerosis. These effects were related in part to a better balance in the synthesis and absorption of sterols.
Keywords Euterpe oleracea (acai)
Atherosclerosis
Lipids
Desmosterol
Phytosterols
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number CNPq: 2008/57685-7
Date 2012-01-01
Published in Journal Of Atherosclerosis And Thrombosis. Tokyo: Japan Atherosclerosis Soc, v. 19, n. 3, p. 237-245, 2012.
ISSN 1340-3478 (Sherpa/Romeo, impact factor)
Publisher Japan Atherosclerosis Soc
Extent 237-245
Origin http://doi.org/10.5551/jat.11205
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000303250700004
URI http://repositorio.unifesp.br/11600/44189

Show full item record




File

Name: WOS000303250700004.pdf
Size: 2.683Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account