Resident Peritoneal Inflammatory Cells are Pivotal in the Development of Experimental Atherosclerosis

Resident Peritoneal Inflammatory Cells are Pivotal in the Development of Experimental Atherosclerosis

Author Relvas, Waldir Gabriel Miranda Autor UNIFESP Google Scholar
Izar, Maria Cristina de Oliveira Autor UNIFESP Google Scholar
Segreto, Helena Regina Comodo Autor UNIFESP Google Scholar
Giordani, Adelmo José Autor UNIFESP Google Scholar
Ihara, Silvia Saiuli Miki Autor UNIFESP Google Scholar
Mariano, Mario Autor UNIFESP Google Scholar
Lopes, Jose Daniel Autor UNIFESP Google Scholar
Popi, Ana Flavia Autor UNIFESP Google Scholar
Helfenstein, Tatiana Autor UNIFESP Google Scholar
Pomaro, Daniel Roberto Autor UNIFESP Google Scholar
Póvoa, Rui Manuel dos Santos Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Fonseca, Francisco Antonio Helfenstein Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Aim: Based on evidence that ionizing radiation can ameliorate chronic and autoimmune diseases in patients and experimental animals, we investigated the effects of radiation on the induction and development of experimental atherogenesis.Methods: Male New Zealand rabbits were divided into 5 groups and given an atherogenic diet for 90 days. Peritoneal and thoracic areas (9 Gy) were irradiated on the 1st and 45th days for groups 1 and 2, the 45th day for groups 3 and 4, and not at all for group 5. Prior to irradiation, the peritoneal cavity of animals from groups 1 and 3 was washed with buffered saline. Cells collected by peritoneal washing were reinfused into the peritoneal cavity of the same animal after irradiation. Animals from groups 2 and 4 were intraperitoneally injected with saline as a control.Results: Despite similar lipid profiles among the experimental groups, the percentage of aortas covered by plaques was remarkably reduced (p < 0.001) among animals submitted to irradiation (groups 2 and 4). These differences were completely abolished in irradiated animals reconstituted with their own peritoneal cells.Conclusions: These findings point to an important role of resident inflammatory peritoneal cells in experimental atherogenesis.
Keywords Atherogenesis
Peritoneal cells
Ionizing radiation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-01-01
Published in Journal Of Atherosclerosis And Thrombosis. Tokyo: Japan Atherosclerosis Soc, v. 17, n. 4, p. 378-385, 2010.
ISSN 1340-3478 (Sherpa/Romeo, impact factor)
Publisher Japan Atherosclerosis Soc
Extent 378-385
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000278406000008

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