Werner helicase polymorphism is not associated with Alzheimer's disease

Werner helicase polymorphism is not associated with Alzheimer's disease

Author Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Labio, Roger Willian de Google Scholar
Gatti, Luciano Lobo Autor UNIFESP Google Scholar
Rigolin, Valdeci Oliveira Santos Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Institution Fac Med Marilia
Universidade Federal de São Paulo (UNIFESP)
Abstract Alzheimer disease (AD) is the most common neurodegenerative disorder in the elderly and is also considered a progeroid genetic syndrome. The etiology of AD is complex and the mechanisms underlying its pathophysiology remains to be clarified. Werner syndrome (WS) is a rare autosomal recessive disorder characterized as a segmental progeroid syndrome. The gene (WRN) was recently identified. Its product acts as a DNA helicase and exonuclease. This study investigates the association of AD with the WRN 1367 polymorphisms in samples of 67 DA patients, 56 elderly healthy and 66 young healthy controls. DNA was isolated from blood cells, amplified by PCR and digested with PmaCI. We observed that the genotype distributions of WRN 1367 variants were within Hardy-Weinberg equilibrium in all subject samples. Furthermore, chi-square test comparison for genotype distributions and allele frequencies did not reveal any significant difference among the three groups of subjects (P > 0.05). These results support the idea that these variants are not involved as a risk factor for developing AD.
Keywords Alzheimer's disease
Werner syndrome
WRN 1367 polymorphisms
risk factor
association study
Language English
Date 2004-12-01
Published in Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 6, n. 6, p. 591-594, 2004.
ISSN 1387-2877 (Sherpa/Romeo, impact factor)
Publisher Ios Press
Extent 591-594
Origin http://dx.doi.org/10.3233/JAD-2004-6603
Access rights Closed access
Type Article
Web of Science ID WOS:000227020700003
URI http://repositorio.unifesp.br/11600/44175

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