Apolipoprotein E4 allele and ribosomal genes in Alzheimer's disease

Apolipoprotein E4 allele and ribosomal genes in Alzheimer's disease

Author Tavares, W. M. Google Scholar
Speranca, M. A. Google Scholar
Labio, Roger Willian de Google Scholar
Peres, Clovis de Araujo Autor UNIFESP Google Scholar
Okamoto, Ivan Hideyo Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Institution FAMEMA
Universidade Federal de São Paulo (UNIFESP)
Abstract Ribosomal genes are involved in cellular transcription, translation and gene expression modulation process. An association between 28S/18S rRNA ratio levels with apoptosis and aging has been reported. Moulder et al. [22] and Hashimoto et al. [8] showed an association between apolipoprotein E4 allele and neuronal cell apotosis through diverse mechanisms. The apoE 4 allele is considered a late-onset Alzheimer's disease (AD) risk factor associated with AD pathogenesis. We evaluated the association between apoE4 allele genotyping by PCR and rRNA 28S/18S ratio by slot blotting technique using peripheral blood samples of 18 Alzheimer's disease patients, 18 elderly controls and 18 young controls. A rRNA ratio decrease was observed in AD individuals confirming our previous results but this association is independently of the ApoE4 allele genotype. Thus our results pointed that two different mechanisms are involved in the etiology of Alzheimer disease each one leading independently to cell death. Further studies could investigate these factors.
Keywords ageing
Alzheimer's disease
ribosomal genes
apolipoprotein E
28S/18SrRNA
Language English
Date 2004-08-01
Published in Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 6, n. 4, p. 391-395, 2004.
ISSN 1387-2877 (Sherpa/Romeo, impact factor)
Publisher Ios Press
Extent 391-395
Origin http://dx.doi.org/10.3233/JAD-2004-6406
Access rights Closed access
Type Article
Web of Science ID WOS:000224498300006
URI http://repositorio.unifesp.br/11600/44174

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