Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease

Author	Silva, Patricia Natalia Oliveira da Gigek, Carolina Oliveira Leal, Mariana Ferreira Bertolucci, Paulo Henrique Ferreira Labio, Roger Willian de Payão, Spencer Luiz Marques Smith, Marilia de Arruda Cardoso
Institution	Universidade Federal de São Paulo (UNIFESP) FAMEMA
Abstract	Longevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease ( AD). Methylation Specifc PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p > 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p = 0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis.
Keywords	aging Alzheimer's disease CDH1 DNA methylation epigenetics HTERT SIRT3 SMARCA5
Language	English
Date	2008-01-01
Published in	Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 13, n. 2, p. 173-176, 2008.
ISSN	1387-2877 (Sherpa/Romeo, impact factor)
Publisher	Ios Press
Extent	173-176
Origin	http://dx.doi.org/10.3233/JAD-2008-13207
Access rights	Closed access
Type	Article
Web of Science ID	WOS:000254303500007
URI	http://repositorio.unifesp.br/11600/44173

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