Author |
Silva, Patricia Natalia Oliveira da
![]() ![]() Gigek, Carolina Oliveira ![]() ![]() Leal, Mariana Ferreira ![]() ![]() Bertolucci, Paulo Henrique Ferreira ![]() ![]() Labio, Roger Willian de ![]() Payão, Spencer Luiz Marques ![]() ![]() Smith, Marilia de Arruda Cardoso ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) FAMEMA |
Abstract | Longevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease ( AD). Methylation Specifc PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p > 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p = 0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis. |
Keywords |
aging
Alzheimer's disease CDH1 DNA methylation epigenetics HTERT SIRT3 SMARCA5 |
Language | English |
Date | 2008-01-01 |
Published in | Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 13, n. 2, p. 173-176, 2008. |
ISSN | 1387-2877 (Sherpa/Romeo, impact factor) |
Publisher | Ios Press |
Extent | 173-176 |
Origin |
|
Access rights | Closed access |
Type | Article |
Web of Science ID | WOS:000254303500007 |
URI | http://repositorio.unifesp.br/11600/44173 |
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