Apolipoprotein A-V gene polymorphism -1131T > C and Alzheimer's disease

Apolipoprotein A-V gene polymorphism -1131T > C and Alzheimer's disease

Author Barbosa, Fabio Augusto Freiria Google Scholar
Labio, Roger Willian de Google Scholar
Rigolin, Valdeci Oliveira Santos Autor UNIFESP Google Scholar
Minett, Thaís Soares Cianciarullo Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Institution Fac Med Marilia
Universidade Federal de São Paulo (UNIFESP)
Univ Marilia
Univ Sagrado Coracao
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly and is also considered a progeroid genetic syndrome. The etiology of AD is complex and the mechanisms underlying its pathophysiology remain to be claritied. It has been suggested that a high serum cholesterol level is a risk factor for (AD), and that some polymorphisms of genes encoding proteins regulating cholesterol metabolism are associated with AD development. APOA5 is a recently discovered apolipoprotein involved primarily with triglyceride JG) metabolism disorder. This study investigates the association of AD with the APOA5 gene - 1131T > C polymorphisms in samples of 106 patients with Alzheimer's disease (AD), 76 elderly healthy controls and 93 young healthy controls. DNA samples were isolated from blood cells, amplified by PCR and digested with Tru11. We observed that the genotype distributions of APOA5 variants were within Hardy-Weinberg equilibrium in all subject samples. Furthermore, chi-square test comparison for genotype distributions and allele frequencies did not reveal any significant difference among the three groups of subjects (P > 0.05). These results support the idea that these variants are not involved as a risk factor for developing AD.
Keywords ageing
Alzheimer's disease
apolipoprotein A5
1131T -> polymorphisms
risk factor
Language English
Date 2006-12-01
Published in Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 10, n. 4, p. 365-369, 2006.
ISSN 1387-2877 (Sherpa/Romeo, impact factor)
Publisher Ios Press
Extent 365-369
Origin http://dx.doi.org/10.3233/JAD-2006-10404
Access rights Closed access
Type Article
Web of Science ID WOS:000244120900004
URI http://repositorio.unifesp.br/11600/44171

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