Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables

Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables

Autor Macêdo, G.s. Google Scholar
Ferreira, Carolina.l.p. Google Scholar
Menegaz, Andressa Google Scholar
Arantes, Vanessa Cristina Google Scholar
Veloso, Roberto Vilela Google Scholar
Carneiro, Everardo Magalhães Google Scholar
Boschero, Antonio Carlos Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Latorraca, Marcia Queiroz Google Scholar
Gomes-da-Silva, Maria Helena Gaiva Google Scholar
Instituição Universidade Federal de Mato Grosso Faculdade de Ciências Médicas
Universidade Federal de Mato Grosso Faculdade de Nutrição Departamento de Alimentos e Nutrição
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Resumo During pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17% protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6%). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P < 0.001), but glycemia (F1,19 = 9.02, P = 0.01) and the relative weight of gonadal adipose tissue (F1,19 = 17.11, P < 0.001) were decreased. Pregnancy (F1,19 = 18.13, P < 0.001) and low-protein diet (F1,19 = 20.35, P < 0.001) increased the absolute weight of brown adipose tissue. However, the relative weight of this tissue was increased only by protein restriction (F1,19 = 15.20, P < 0.001) and the relative lipid in carcass was decreased in low-protein groups (F1,19 = 4.34, P = 0.05). Serum insulin and leptin levels were similar among groups and did not correlate with food intake. However, there was a positive relationship between serum insulin levels and carcass fat depots in low-protein groups (r = 0.37, P < 0.05), while in pregnancy serum leptin correlated with weight of gonadal (r = 0.39, P < 0.02) and retroperitoneal (r = 0.41, P < 0.01) adipose tissues. Unexpectedly, protein restriction during 14 days of pregnancy did not alter the serum profile of adiposity signals and their effects on food intake and adiposity, probably due to the short term of exposure to low-protein diet.
Palavra-chave Low-protein diet
Pregnancy
Serum leptin
Serum insulin
Body adiposity
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Brazilian Foundations FAPEMAT
Número do financiamento Brazilian Foundations FAPEMAT: 175/04
CNPq: 479138/2003-6
Data de publicação 2008-06-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 6, p. 519-525, 2008.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 519-525
Fonte http://dx.doi.org/10.1590/S0100-879X2008000600014
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000258766600014
SciELO S0100-879X2008000600014 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4411

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