Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer

Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer

Author Siufi, Adalberto Abraao Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Dardes, Rita de Cássia de Maio Autor UNIFESP Google Scholar
Takita, Luiz Carlos Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Goncalves, Wagner Jose Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The cyclin-dependent kinase inhibitor, p27, has been shown to mediate cell growth arrest thereby significantly reducing the percentage of proliferating cells. It seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis. Our aim was to demonstrate the effects of tamoxifen therapy on the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. Fifty-three pre- and post-tamoxifen treatment endometrium samples were examined immunohistochemically using p27 antibody. Tamoxifen therapy (20 mg/day) for 60 days increased the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. We conclude that tamoxifen therapy does not seem to be directly involved in the carcinogenesis of endometrial carcinoma since the expression of p27 is not decreased.
Keywords endometrium
tamoxifen
p27
Language English
Date 2003-12-01
Published in International Journal Of Oncology. Athens: Professor D A Spandidos, v. 23, n. 6, p. 1545-1551, 2003.
ISSN 1019-6439 (Sherpa/Romeo, impact factor)
Publisher Professor D A Spandidos
Extent 1545-1551
Origin https://doi.org/10.3892/ijo.23.6.1545
Access rights Closed access
Type Article
Web of Science ID WOS:000186674200008
URI http://repositorio.unifesp.br/11600/44091

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