A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer

A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer

Author Dardes, Rita de Cássia de Maio Autor UNIFESP Google Scholar
Horiguchi, J. Autor UNIFESP Google Scholar
Jordan, V. C. Autor UNIFESP Google Scholar
Institution Northwestern Univ
Universidade Federal de São Paulo (UNIFESP)
Gunma Univ
Abstract In this study we demonstrate the change in estrogen receptor (ER) level and cell proliferation in human breast cancer after a short-term tamoxifen therapy. Ten pre and post-treatment breast tumor samples were examined immunohistochemically using ER and Ki-67 antibodies. Before tamoxifen treatment, six (60%) of ten patients were positive for ER. Tamoxifen increased the ER level in one patient and decreased the level in 4 patients. There was no significant change in ER level by tamoxifen therapy. On the other hand, Ki-67 labelling index (LI) significantly decreased after tamoxifen treatment. When Ki-67 LI was analyzed according to ER level, there was no difference between pre- and post-tamoxifen treatment in ER-negative patients, however, a significant decrease of Ki-67 LI by tamoxifen treatment was seen in ER-positive patients. Patients who showed down-regulation of ER expression tended to show a decrease of Ki-67 LI after tamoxifen therapy. In conclusion, short-term tamoxifen therapy decreased the proliferation of breast cancer, in ER-positive breast tumor samples.
Keywords breast cancer
tamoxifen
estrogen receptor
Ki-67
Language English
Date 2000-01-01
Published in International Journal Of Oncology. Athens: Professor D A Spandidos, v. 16, n. 1, p. 25-30, 2000.
ISSN 1019-6439 (Sherpa/Romeo, impact factor)
Publisher Professor D A Spandidos
Extent 25-30
Origin https://doi.org/10.3892/ijo.16.1.25
Access rights Closed access
Type Article
Web of Science ID WOS:000084315200003
URI http://repositorio.unifesp.br/11600/44090

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