A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer

A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer

Autor Dardes, Rita de Cássia de Maio Autor UNIFESP Google Scholar
Horiguchi, J. Autor UNIFESP Google Scholar
Jordan, V. C. Autor UNIFESP Google Scholar
Instituição Northwestern Univ
Universidade Federal de São Paulo (UNIFESP)
Gunma Univ
Resumo In this study we demonstrate the change in estrogen receptor (ER) level and cell proliferation in human breast cancer after a short-term tamoxifen therapy. Ten pre and post-treatment breast tumor samples were examined immunohistochemically using ER and Ki-67 antibodies. Before tamoxifen treatment, six (60%) of ten patients were positive for ER. Tamoxifen increased the ER level in one patient and decreased the level in 4 patients. There was no significant change in ER level by tamoxifen therapy. On the other hand, Ki-67 labelling index (LI) significantly decreased after tamoxifen treatment. When Ki-67 LI was analyzed according to ER level, there was no difference between pre- and post-tamoxifen treatment in ER-negative patients, however, a significant decrease of Ki-67 LI by tamoxifen treatment was seen in ER-positive patients. Patients who showed down-regulation of ER expression tended to show a decrease of Ki-67 LI after tamoxifen therapy. In conclusion, short-term tamoxifen therapy decreased the proliferation of breast cancer, in ER-positive breast tumor samples.
Assunto breast cancer
tamoxifen
estrogen receptor
Ki-67
Idioma Inglês
Data 2000-01-01
Publicado em International Journal Of Oncology. Athens: Professor D A Spandidos, v. 16, n. 1, p. 25-30, 2000.
ISSN 1019-6439 (Sherpa/Romeo, fator de impacto)
Editor Professor D A Spandidos
Extensão 25-30
Fonte https://doi.org/10.3892/ijo.16.1.25
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000084315200003
URI http://repositorio.unifesp.br/11600/44090

Mostrar registro completo




Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)