Interleukin-6 polymorphisms and the risk of cervical cancer

Interleukin-6 polymorphisms and the risk of cervical cancer

Author Souza, NCN de Google Scholar
Brenna, SMF Google Scholar
Campos, F. Google Scholar
Syrjanen, K. J. Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Leonor Mendes Barros Matern Hosp
Turku Univ
Abstract Recent data implicate that cytokine gene polymorphisms are important in pathogenesis of various neoplastic and nonneoplastic human diseases, and it was recently suggested that polymorphisms in interleukin (IL)-6 might increase the risk of gynecological malignancies, including cervical carcinomas. The aim of this case-control study is to compare the IL-6 polymorphisms in cervical cancer patients and healthy controls and to assess whether any of these polymorphisms would increase the risk of developing cervical cancer. The material in this case-control study consists of 56 patients with cervical carcinoma and 253 population-based control subjects, all ethnic Brazilian women. Control subjects were cancer-free women, following a negative cervical cytology and colposcopy. IL-6 genotyping was performed using a polymerase chain reaction-based restriction fragment length polymorphism. Distribution of the GG, GC, and CC genotypes in cases and controls was significantly different (P = 0.033). Compared with the GG genotype as reference, the adjusted odds ratio for the combined GC and CC genotypes in cancer patients was 1.90 (95% confidence interval, 1.1-3.4). These data suggest that women carrying at least one C genotype in their IL-6 promoter region (-174G -> C) are at higher risk of developing cervical cancer.
Keywords cervical cancer
IL-6
polymorphisms
risk factor
Language English
Date 2006-05-01
Published in International Journal Of Gynecological Cancer. Oxford: Blackwell Publishing, v. 16, n. 3, p. 1278-1282, 2006.
ISSN 1048-891X (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 1278-1282
Origin http://doi.org/10.1111/j.1525-1438.2006.00521.x
Access rights Closed access
Type Article
Web of Science ID WOS:000238255300049
URI http://repositorio.unifesp.br/11600/44044

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