Effects of early and late adverse experiences on morphological characteristics of Sprague-Dawley rat liver subjected to stress during adulthood

Effects of early and late adverse experiences on morphological characteristics of Sprague-Dawley rat liver subjected to stress during adulthood

Author Vasquez, Belgica Google Scholar
Sandoval, Cristian Google Scholar
Smith, Ricardo Luiz Autor UNIFESP Google Scholar
del Sol, Mariano Google Scholar
Institution Univ La Frontera
Univ Tarapaca
Universidade Federal de São Paulo (UNIFESP)
Univ Autonoma Chile
Abstract The literature indicates that early rupture of the maternal bond and social isolation are variables involved in social and emotional behaviors and in increase in anxiety, particularly in stressful situations. The liver plays a role in the adaptation to stress, yet the possible morphologic changes that its structure can suffer have been studied very little. Therefore, the aim here was to ascertain, through the model of altering the early mother-infant bond and the late social bond through isolation, the effect on the stereologic characteristics of the liver in adult Sprague-Dawley rats subjected to intermittent chronic stress. Twenty-five newborn female rats were used, distributed into 5 groups, under standardized lactation and feeding conditions. The experimental groups were exposed to early (E1), late (E2), and early-late (E3) adverse experiences and then subjected to intermittent chronic stress in adulthood. The liver of each animal was isolated, and the stereologic characteristics of Nv, Vv, and Sv of the hepatocytes were determined. The results from the experimental groups were significantly higher than those obtained in the control groups. The highest values were found in group E3 (Nv = 4.43 +/- 0.89 x 10(5)/mm(3), Vv = 68.74 +/- 2.01%, Sv = 68.78 +/- 3.77 mm(2)/mm(3)). Considering these results, the hepatic morphology can be affected by exposure to chronic stress; however, when the individuals have been subjected to previous adverse experiences, the changes are more evident.
Keywords Adverse experience
stress
liver
rat
morphology
Language English
Date 2014-01-01
Published in International Journal Of Clinical And Experimental Pathology. Madison: E-century Publishing Corp, v. 7, n. 8, p. 4627-4635, 2014.
ISSN 1936-2625 (Sherpa/Romeo, impact factor)
Publisher E-century Publishing Corp
Extent 4627-4635
Origin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152025/
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000345120900007
URI http://repositorio.unifesp.br/11600/44035

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