E-cadherin and metalloproteinase-1 and-7 polymorphisms in colorectal cancer

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dc.contributor.author Lima, Jacqueline Miranda de [UNIFESP]
dc.contributor.author Souza, Lessileia Gomes de
dc.contributor.author Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.author Forones, Nora Manoukian [UNIFESP]
dc.date.accessioned 2018-06-15T17:44:17Z
dc.date.available 2018-06-15T17:44:17Z
dc.date.issued 2009-04-01
dc.identifier http://www.biological-markers.com/article/e-cadherin-and-metalloproteinase-1-and--7-polymorphisms-in-colorectal-cancer-art005943
dc.identifier.citation International Journal Of Biological Markers. Milan: Wichtig Editore, v. 24, n. 2, p. 99-106, 2009.
dc.identifier.issn 0393-6155
dc.identifier.uri http://repositorio.unifesp.br/11600/44026
dc.description.abstract Purpose: E-cadherin (CDH1) and metalloproteinase (MMP) polymorphisms could play a crucial role in cancer invasion. Our aim was to investigate the influence of the -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 polymorphisms on the frequency and progression of colorectal cancer (CRC).Experimental design: A total of 130 patients with CRC and 130 noncancer controls were studied. The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.Results: Patients with the 1 G allele and a family history of CRC showed a six times higher risk of developing CRC (OR: 6.45, 95%CI: 2.02-20.6, p=0.001). The A/A CDH1 genotype was associated with a higher risk of metastatic disease (OR: 3.43, 95%CI: 1.27-9.27, p=0.023). A higher marginal risk of metastatic disease was observed for MMP-1 genotypes 1G/1G and 1G/2G (OR: 2.97, 95%CI: 0.93-9.47, p=0.098).Conclusions: The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 single nucleotide polymorphisms did not modify the risk of CRC development. Patients with the 1G/1G or 1G/2G genotype and a family history of CRC presented a higher risk of CRC. The AA CDH1 and 1G/1G and 1G/2G MMP-1 genotypes might be associated with advanced metastatic disease, but are not markers of lymphatic metastasis. (Int J Biol Markers 2009; 24: 99-106) en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 99-106
dc.language.iso eng
dc.publisher Wichtig Editore
dc.relation.ispartof International Journal Of Biological Markers
dc.rights Acesso restrito
dc.subject E-cadherin en
dc.subject Metalloproteinases en
dc.subject MMP-1 en
dc.subject MMP-7 en
dc.subject Colorectal cancer en
dc.title E-cadherin and metalloproteinase-1 and-7 polymorphisms in colorectal cancer en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Disciplina Gastroenterol Clin, Div Gastroenterol, Oncol Grp,EPM, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Disciplina Gastroenterol Clin, Div Gastroenterol, Oncol Grp,EPM, BR-04023900 Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000270156400006



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