E-cadherin and metalloproteinase-1 and-7 polymorphisms in colorectal cancer

E-cadherin and metalloproteinase-1 and-7 polymorphisms in colorectal cancer

Author Lima, Jacqueline Miranda de Autor UNIFESP Google Scholar
Souza, Lessileia Gomes de Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: E-cadherin (CDH1) and metalloproteinase (MMP) polymorphisms could play a crucial role in cancer invasion. Our aim was to investigate the influence of the -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 polymorphisms on the frequency and progression of colorectal cancer (CRC).Experimental design: A total of 130 patients with CRC and 130 noncancer controls were studied. The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.Results: Patients with the 1 G allele and a family history of CRC showed a six times higher risk of developing CRC (OR: 6.45, 95%CI: 2.02-20.6, p=0.001). The A/A CDH1 genotype was associated with a higher risk of metastatic disease (OR: 3.43, 95%CI: 1.27-9.27, p=0.023). A higher marginal risk of metastatic disease was observed for MMP-1 genotypes 1G/1G and 1G/2G (OR: 2.97, 95%CI: 0.93-9.47, p=0.098).Conclusions: The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 single nucleotide polymorphisms did not modify the risk of CRC development. Patients with the 1G/1G or 1G/2G genotype and a family history of CRC presented a higher risk of CRC. The AA CDH1 and 1G/1G and 1G/2G MMP-1 genotypes might be associated with advanced metastatic disease, but are not markers of lymphatic metastasis. (Int J Biol Markers 2009; 24: 99-106)
Keywords E-cadherin
Metalloproteinases
MMP-1
MMP-7
Colorectal cancer
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2009-04-01
Published in International Journal Of Biological Markers. Milan: Wichtig Editore, v. 24, n. 2, p. 99-106, 2009.
ISSN 0393-6155 (Sherpa/Romeo, impact factor)
Publisher Wichtig Editore
Extent 99-106
Origin http://www.biological-markers.com/article/e-cadherin-and-metalloproteinase-1-and--7-polymorphisms-in-colorectal-cancer-art005943
Access rights Closed access
Type Article
Web of Science ID WOS:000270156400006
URI http://repositorio.unifesp.br/11600/44026

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