The bone marrow cells radioprotection by amifostine - NN/N ratio, apoptosis, ultrastructural and lipid matrix evaluation

The bone marrow cells radioprotection by amifostine - NN/N ratio, apoptosis, ultrastructural and lipid matrix evaluation

Author Segreto, Roberto Araujo Autor UNIFESP Google Scholar
Egami, Mizue Imoto Autor UNIFESP Google Scholar
França, Jerônimo Pereira de Autor UNIFESP Google Scholar
Silva, MRR Google Scholar
Ferreira, Alice Teixeira Autor UNIFESP Google Scholar
Segreto, Helena Regina Comodo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The present experiment was performed in order to estimate the amifostine-WR2721 (ami) bone marrow cells radioprotection, by the following parameters. NN/N ratio, the apoptotic cell counting, ultrastructural analysis and lipid matrix (membrane) injury evaluation.The protected marrows showed: significant low NN/N ratio (24h); significant low number of apoptotic cells (4,12h); better ultrastructural aspect (4,12,24h and 10 days); less lipid matrix injury (4h). These findings show that amifostine is an efficient radioprotector for the bone marrow cells.
Keywords bone marrow
ionizing radiation
radioprotector
Language English
Date 1999-04-01
Published in Interciencia. Caracas: Interciencia, v. 24, n. 2, p. 127-134, 1999.
ISSN 0378-1844 (Sherpa/Romeo, impact factor)
Publisher Interciencia
Extent 127-134
Access rights Closed access
Type Article
Web of Science ID WOS:000080460400009
URI http://repositorio.unifesp.br/11600/43983

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