Attaching and effacing enteropathogenic Escherichia coli 018ab invades epithelial cells and causes persistent diarrhea

Attaching and effacing enteropathogenic Escherichia coli 018ab invades epithelial cells and causes persistent diarrhea

Author Scaletsky, Isabel Cristina Affonso Autor UNIFESP Google Scholar
Pedroso, Margareth Zabeu Autor UNIFESP Google Scholar
Fagundes Neto, Ulysses Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract A case of persistent diarrhea following Escherichia coli O18ab gastroenteritis is reported, Electron microscopy of a biopsy of the small intestine showed effacement of the brush border attachment of bacteria to the epithelial cells with pedestal formation, and bacteria within the enterocytes. The bacterial isolate was an enteropathogenic E, coli isolate which did not contain the adherence factor (EAF) but possessed the attaching-effacing eae gene, was able to invade HeLa cells in a gentamicin invasion assay, and also invaded rabbit intestinal cells, Results suggest that E. coli organisms of the O18ab serotype may cause diarrhea by an as get unknown pathogenic mechanism, involving attaching to and effacing of enterocytes followed by invasion of the epithelial cells.
Language English
Date 1996-11-01
Published in Infection And Immunity. Washington: Amer Soc Microbiology, v. 64, n. 11, p. 4876-4881, 1996.
ISSN 0019-9567 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 4876-4881
Origin http://iai.asm.org/content/64/11/4876.abstract
Access rights Closed access
Type Article
Web of Science ID WOS:A1996VP42800072
URI http://repositorio.unifesp.br/11600/43957

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