Expression of galectin-3 in gastric adenocarcinoma

Expression of galectin-3 in gastric adenocarcinoma

Author Gomes, Thiago Simao Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Lima, Flavio de Oliveira Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background & objectives: Galectin-3 a member of the galectin family is an endogenous beta-galactoside binding lectin. It has been found to be associated with cell adhesion, recognition, proliferation, differentiation, immunomodulation, angiogenesis, apoptosis and can be a reliable marker for cancer aggressiveness. The aim of this study was to verify protein expression in gastric adenocarcinoma tissues and correlate the results with the clinical aspects in the study population.Methods: Galectin-3 expression was examined by immunohistochemistry in 57 samples of gastric adenocarcinomas tissues. Galectin-3 protein expression was observed in the cytoplasm and the nucleus of examined tissues.Results: Thirty one (54.4%) samples had strong or moderate staining and 26 (45.6%) tumours had negative or weak staining. The galectin-3 did not show association with the sex (p=0.347), age (p=0.999), Lauren's classification (p=0.731) and TNM stage (p=0.222). Regarding the TNM stage, 66.7 per cent of stage I tumours had strong or moderate staining; with tumours stage IV this percentage was 33.3 per cent.Interpretation & conclusion: Our results suggest that gal-3 is not a reliable biomarker for prognosis of the gastric adenocarcinoma by immunohistochemistry. Further studies need to be done on a large sample of tumour tissues in different clinical staging.
Keywords Biomarker
galectin-3
gastric adenocarcinoma
immunoexpression
prognosis
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2014-07-01
Published in Indian Journal Of Medical Research. New Delhi: Indian Council Medical Res, v. 140, p. 69-76, 2014.
ISSN 0971-5916 (Sherpa/Romeo, impact factor)
Publisher Indian Council Medical Res
Extent 69-76
Origin http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=1;spage=69;epage=76;aulast=Gomes;type=0
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000341775800012
URI http://repositorio.unifesp.br/11600/43922

Show full item record




File

Name: WOS000341775800012.pdf
Size: 631.1Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account