In Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis

In Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis

Author Noguti, Juliana Autor UNIFESP Google Scholar
Barbisan, Luis Fernando Google Scholar
Cesar, Augusto Autor UNIFESP Google Scholar
Pereira, Camilo Dias Seabra Autor UNIFESP Google Scholar
Choueri, Rodrigo Brasil Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk.
Keywords Cancer
in vivo models
GST-P 7-7
review
Language English
Date 2012-07-01
Published in In Vivo. Athens: Int Inst Anticancer Research, v. 26, n. 4, p. 647-650, 2012.
ISSN 0258-851X (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 647-650
Origin http://iv.iiarjournals.org/content/26/4/647.full
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000306397000018
URI http://repositorio.unifesp.br/11600/43917

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