Expression Profiling of Cell Cycle Regulatory Proteins in Oropharyngeal Carcinomas Using Tissue Microarrays

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dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.contributor.author Nascimento, Fábio Dupart [UNIFESP]
dc.contributor.author Fracalossi, Ana Carolina Cuzzuol [UNIFESP]
dc.contributor.author Gomes, Thiago Simao [UNIFESP]
dc.contributor.author Oshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.author Franco, Marcello Fabiano de [UNIFESP]
dc.date.accessioned 2018-06-15T17:38:31Z
dc.date.available 2018-06-15T17:38:31Z
dc.date.issued 2010-05-01
dc.identifier http://iv.iiarjournals.org/content/24/3/315.full
dc.identifier.citation In Vivo. Athens: Int Inst Anticancer Research, v. 24, n. 3, p. 315-320, 2010.
dc.identifier.issn 0258-851X
dc.identifier.uri http://repositorio.unifesp.br/11600/43915
dc.description.abstract Aim: The aim of this study was to investigate the expressions of cell cycle regulatory proteins such as p53, p16, p21, and Rb in squamous cell carcinoma of the oropharynx and their relation to histological differentiation, staging of disease, and prognosis. Patients and Methods: Paraffin blocks from 21 primary tumors were obtained from archives of the Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM. Immunohistochemistry was used to detect the expression of p53, p16, p21, and Rb by means of tissue microarrays. Results: Expression of p53, p21, p16 and Rb was not correlated with the stage of disease, histopathological grading or recurrence in squamous cell carcinoma of the oropharynx. Conclusion: Taken together, our results suggest that p53, p16, p21 and Rb are not reliable biomarkers for prognosis of the tumor severity or recurrence in squamous cell carcinoma of the oropharynx as depicted by tissue microarrays and immunohistochemistry. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho de Desenvolvimento Cientifico e Tecnologico
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 315-320
dc.language.iso eng
dc.publisher Int Inst Anticancer Research
dc.relation.ispartof In Vivo
dc.rights Acesso aberto
dc.subject Squamous cell carcinomas en
dc.subject tissue microarray en
dc.subject immunohistochemistry en
dc.subject p53 en
dc.subject p16 en
dc.subject p21 en
dc.subject Rb en
dc.title Expression Profiling of Cell Cycle Regulatory Proteins in Oropharyngeal Carcinomas Using Tissue Microarrays en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Patol, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Patol, BR-11060001 Santos, SP, Brazil
dc.description.sponsorshipID FAPESP: 07/01228-4
dc.description.source Web of Science
dc.identifier.wos WOS:000279035400011



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