Chromosome X Aneuploidy in Brazilian Schizophrenic Patients

Chromosome X Aneuploidy in Brazilian Schizophrenic Patients

Author De Moraes, Leopoldo Silva Google Scholar
Khayat, Andre Salim Autor UNIFESP Google Scholar
Lima De Lima, Patricia Danielle Google Scholar
Lima, Eleonidas Moura Google Scholar
Pinto, Giovanny Reboucas Google Scholar
Leal, Mariana Ferreira Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Burbano, Rommel Rodriguez Autor UNIFESP Google Scholar
Institution Univ Fed Piaui
Fed Univ Para
Universidade Federal de São Paulo (UNIFESP)
Abstract The identification of cytogenetic abnormalities in schizophrenic patients may provide clues to the genes involved in this disease. For this reason, a chromosomal analysis of samples from 62 schizophrenics and 70 controls was performed with trypsin-Giemsa banding and fluorescence in situ hybridization of the X chromosome. A clonal pericentric inversion on chromosome 9 was detected in one male patient, and we also discovered mosaicism associated with X chromosome aneuploidy in female patients, primarily detected in schizophrenic and normal female controls over 40 years old. When compared with age-matched female controls, the frequency of X chromosome loss was not significantly different between schizophrenics and controls, except for the 40- to 49-year-old age group. Our findings suggest that the X chromosome loss seen in schizophrenic patients is inherent to the normal cellular aging process. However, our data also suggest that X chromosome gain may he correlated with schizophrenia in this Brazilian population.
Keywords Aneuploidy
chromosome X
GTG-banding
fluorescence in situ hybridization
schizophrenia
Language English
Sponsor Financiadora de Estudos e Projetos (FINEP CT-INFRA/FADESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundacao de Amparo e Desenvolvimento da Pesquisa (FADESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2010-05-01
Published in In Vivo. Athens: Int Inst Anticancer Research, v. 24, n. 3, p. 279-284, 2010.
ISSN 0258-851X (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 279-284
Origin http://iv.iiarjournals.org/content/24/3/281.long
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000279035400005
URI http://repositorio.unifesp.br/11600/43914

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