FAMILIAL HYPERTENSION AND ALBUMINURIA IN NORMOTENSIVE TYPE-I DIABETIC-PATIENTS

FAMILIAL HYPERTENSION AND ALBUMINURIA IN NORMOTENSIVE TYPE-I DIABETIC-PATIENTS

Author Freire, Maria Beatriz Sayeg Autor UNIFESP Google Scholar
Ferreira, Sandra Roberta Gouvea Autor UNIFESP Google Scholar
Vivolo, Marco Antonio Autor UNIFESP Google Scholar
Oliveira, J. M. Google Scholar
Zanella, Maria Teresa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
FAC MED JUNDIAI
Universidade Federal Fluminense (UFF)
Abstract An inherited predisposition to hypertension may increase susceptibility to nephropathy in type I diabetes. We evaluated the influence of a family history of essential hypertension on albuminuria in normotensive, normoalbuminuric type I diabetic patients. Forty-two diabetics (12.9+/-2.04 years) were divided into three groups according to tertiles of albumin excretion rate (group 1, 1.27+/-0.35; group 2, 2.43+/-0.49; group 3, 6.37+/-3.43 mu g/min; P<.001). Familial hypertension was considered to be present if the patient had one parent or grandparent on antihypertensive therapy. The three groups did not differ concerning age, diabetes duration, insulin requirement, body mass index, blood pressure, and urinary glucose excretion. Albumin excretion rate did not correlate with any parameter studied. The frequency of hypertension was significantly lower among the relatives of the patients from group 1 compared with those from groups 2 and 3 (28.6% versus 64.3% versus 78.6%, P<.03). Our data suggest that a familial antecedent of hypertension in normoalbuminuric type I diabetic patients is associated with a high normal albumin excretion rate not related to increases in blood pressure. Early changes in renal hemodynamics, seen in patients with a predisposition to hypertension, may contribute to increments in albuminuria even within the normal range.
Keywords DIABETES MELLITUS, INSULIN-DEPENDENT
HYPERTENSION, ESSENTIAL
ALBUMINURIA
DIABETIC NEPHROPATHIES
Language English
Date 1994-01-01
Published in Hypertension. Dallas: Amer Heart Assoc, v. 23, n. 1, p. I256-I258, 1994.
ISSN 0194-911X (Sherpa/Romeo, impact factor)
Publisher Amer Heart Assoc
Extent I256-I258
Origin https://doi.org/10.1161/01.HYP.23.1_Suppl.I256
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1994MR84300055
URI http://repositorio.unifesp.br/11600/43819

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account