ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY

ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY

Author Gerbase-Lima, Maria Autor UNIFESP Google Scholar
Ladalardo, Maria Antonia Autor UNIFESP Google Scholar
Delima, JJG Google Scholar
Silva, H. B. Google Scholar
Bellotti, G. Google Scholar
Pileggi, F. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Data from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population.
Keywords ESSENTIAL HYPERTENSION
HLA ANTIGENS
IMMUNOGENETICS
HISTOCOMPATIBILITY ANTIGENS
Language English
Date 1992-04-01
Published in Hypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992.
ISSN 0194-911X (Sherpa/Romeo, impact factor)
Publisher Amer Heart Assoc
Extent 400-402
Origin https://doi.org/10.1161/01.HYP.19.4.400
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1992HM35400016
URI http://repositorio.unifesp.br/11600/43817

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