Parathyroid glands in uraemic patients with refractory hyperparathyroidism: histopathology and p53 protein expression analysis

Parathyroid glands in uraemic patients with refractory hyperparathyroidism: histopathology and p53 protein expression analysis

Author Martin, Luciana Neves Consenso Autor UNIFESP Google Scholar
Kayath, Marcia Jeha Autor UNIFESP Google Scholar
Vieira, Jose Gilberto Henriques Autor UNIFESP Google Scholar
Nose-Alberti, V Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Aims: Refractory hyperparathyroidism is a state of parathyroid hyperfunction and hypercalcaemia in uraernic patients with previous secondary hyperplasia. We studied histopathological features and p53 expression in 49 parathyroid glands of uraemic patients (n=21) with refractory hyperparathyroidism in order to investigate whether p53 abnormalities could be present in parathyroid hyperplasias of chronic renal failure.Methods and results: Nodular hyperplasia was found in 77.5% of the glands (n = 38). The proportion of oxyphil cells and acinar cell arrangements was higher in nodular hyperplasia than in diffuse hyperplastic glands (P<0.001), Duration of renal disease and haemodialysis treatment tended to be longer in patients with nodular hyperplasia, There was no correlation between serum intact PTH (iPTH), calcium and hyperplasia pattern, A trend for a higher glandular mass was found in nodular type hyperplasia (1.88 +/- 2.13 g) than in diffuse type hyperplasia (0.87+/-1.28g; P=0.06). Nuclear p53 immunoreactivity was shown in 55% of the hyperplastic glands, whereas it was not detected in 12 normal parathyroid glands used as controls. p53 staining was present in c, 82% of the diffuse hyperplastic glands and in 47% of the nodular hyperplastic glands (P=0.08),Conclusions: Nodular type hyperplasia was the predominant histopathological pattern in uraemic patients with refractory hyperparathyroidism in our study. Nodular hyperplastic glands characteristically had higher percentage of oxyphil cells, acinar cell arrangements and mass than diffuse hyperplastic glands. A high prevalence of p53 protein expression was found in hyperplastic glands of uraemic patients. Our results suggest that p53 abnormalities might be involved in the pathogenesis of parathyroid hyperplasia in chronic renal failure.
Keywords hyperparathyroidism
p53
parathyroid gland
parathyroid hyperplasia
uraemia
Language English
Date 1998-07-01
Published in Histopathology. Oxford: Blackwell Science Ltd, v. 33, n. 1, p. 46-51, 1998.
ISSN 0309-0167 (Sherpa/Romeo, impact factor)
Publisher Blackwell Science Ltd
Extent 46-51
Origin http://doi.org/10.1046/j.1365-2559.1998.00459.x
Access rights Closed access
Type Article
Web of Science ID WOS:000075318200007
URI http://repositorio.unifesp.br/11600/43799

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