Study of immunohistochemical expression of insulin-like growth factor I and proliferating cell nuclear antigen in thyroid gland papillary carcinoma and its metastasis

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dc.contributor.author Silva, G. B.
dc.contributor.author Maciel, Rui Monteiro de Barros [UNIFESP]
dc.contributor.author Takahashi, Mirian Hideco [UNIFESP]
dc.contributor.author Alberti, Vania Nose [UNIFESP]
dc.contributor.author Castro, IV
dc.contributor.author Saldiva, Paulo Hilário Nascimento [UNIFESP]
dc.contributor.author Durazzo, M. D.
dc.contributor.author Ferraz, A. R.
dc.date.accessioned 2018-06-15T17:30:23Z
dc.date.available 2018-06-15T17:30:23Z
dc.date.issued 1999-12-01
dc.identifier https://doi.org/10.1002/(SICI)1097-0347(199912)21:8<723
dc.identifier.citation Head And Neck-journal For The Sciences And Specialties Of The Head And Neck. New York: John Wiley & Sons Inc, v. 21, n. 8, p. 723-727, 1999.
dc.identifier.issn 1043-3074
dc.identifier.uri http://repositorio.unifesp.br/11600/43742
dc.description.abstract Background. Several tumor factors are associated with papillary thyroid cancer. Most studies do not compare the expressions of these factors in the primary tumors and in their associated cervical metastasis.Methods. Paraffin sections of 20 patients with papillary carcinoma of the thyroid gland with lymph node metastasis were studied. The presence and distribution of insulin-like growth factor I (IGF-I) and proliferating cell nuclear antigen (PCNA) was analyzed, through immunohistochemical technique, in both primaries and lymph node metastasis. The results were correlated with clinical-pathologic data (sex, age, size of primary, multicentricity, thyroid capsule invasion, lymphatic and blood vessels invasion, development of distant metastasis, and associated thyroid diseases).Results. The qualitative analysis showed the reaction for IGF-I was present in more than 90% of the neoplastic cells in both primaries and lymph node metastasis. No correlation with the clinical-pathlogical features was observed. Regarding the PCNA, the mean percentage of nuclei stained showed no statistical difference between primaries and metastasis (p = 0.598). Except for age, clinicopathologic data had no influence on the mean percentage of nuclei stained. A correlation was verified between the percentage of cells stained by PCNA in primary tumors and the patients' age (p < 0.01).Conclusions. The expressions of these tumor factors are equally intense for both primary and metastatic tissue in papillary thyroid cancer. Despite the small size of the sample, the expressions of ICE-I and PCNA could not be associated to clinical-pathologic features, except for the age. As patients over 40 years old had higher expression of PCNA, this marker may have prognostic significance for patients with papillary thyroid cancer. (C) 1999 John Wiley & Sons, Inc. Head Neck 21: 723-727, 1999. en
dc.format.extent 723-727
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Head And Neck-journal For The Sciences And Specialties Of The Head And Neck
dc.rights Acesso restrito
dc.subject papillary thyroid cancer en
dc.subject thyroid cancer en
dc.subject PCNA en
dc.subject IGF-I en
dc.title Study of immunohistochemical expression of insulin-like growth factor I and proliferating cell nuclear antigen in thyroid gland papillary carcinoma and its metastasis en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Sao Paulo, Dept Surg, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Med, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Med, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil
dc.identifier.doi 10.1002/(SICI)1097-0347(199912)21:8<723
dc.description.source Web of Science
dc.identifier.wos WOS:000083844700006



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