Study of immunohistochemical expression of insulin-like growth factor I and proliferating cell nuclear antigen in thyroid gland papillary carcinoma and its metastasis

Study of immunohistochemical expression of insulin-like growth factor I and proliferating cell nuclear antigen in thyroid gland papillary carcinoma and its metastasis

Author Silva, G. B. Google Scholar
Maciel, Rui Monteiro de Barros Autor UNIFESP Google Scholar
Takahashi, Mirian Hideco Autor UNIFESP Google Scholar
Alberti, Vania Nose Autor UNIFESP Google Scholar
Castro, IV Google Scholar
Saldiva, Paulo Hilário Nascimento Autor UNIFESP Google Scholar
Durazzo, M. D. Google Scholar
Ferraz, A. R. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background. Several tumor factors are associated with papillary thyroid cancer. Most studies do not compare the expressions of these factors in the primary tumors and in their associated cervical metastasis.Methods. Paraffin sections of 20 patients with papillary carcinoma of the thyroid gland with lymph node metastasis were studied. The presence and distribution of insulin-like growth factor I (IGF-I) and proliferating cell nuclear antigen (PCNA) was analyzed, through immunohistochemical technique, in both primaries and lymph node metastasis. The results were correlated with clinical-pathologic data (sex, age, size of primary, multicentricity, thyroid capsule invasion, lymphatic and blood vessels invasion, development of distant metastasis, and associated thyroid diseases).Results. The qualitative analysis showed the reaction for IGF-I was present in more than 90% of the neoplastic cells in both primaries and lymph node metastasis. No correlation with the clinical-pathlogical features was observed. Regarding the PCNA, the mean percentage of nuclei stained showed no statistical difference between primaries and metastasis (p = 0.598). Except for age, clinicopathologic data had no influence on the mean percentage of nuclei stained. A correlation was verified between the percentage of cells stained by PCNA in primary tumors and the patients' age (p < 0.01).Conclusions. The expressions of these tumor factors are equally intense for both primary and metastatic tissue in papillary thyroid cancer. Despite the small size of the sample, the expressions of ICE-I and PCNA could not be associated to clinical-pathologic features, except for the age. As patients over 40 years old had higher expression of PCNA, this marker may have prognostic significance for patients with papillary thyroid cancer. (C) 1999 John Wiley & Sons, Inc. Head Neck 21: 723-727, 1999.
Keywords papillary thyroid cancer
thyroid cancer
PCNA
IGF-I
Language English
Date 1999-12-01
Published in Head And Neck-journal For The Sciences And Specialties Of The Head And Neck. New York: John Wiley & Sons Inc, v. 21, n. 8, p. 723-727, 1999.
ISSN 1043-3074 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 723-727
Origin https://doi.org/10.1002/(SICI)1097-0347(199912)21:8<723
Access rights Closed access
Type Article
Web of Science ID WOS:000083844700006
URI http://repositorio.unifesp.br/11600/43742

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