INVESTIGATION OF THE NUCLEOLAR ORGANIZER REGIONS IN ALZHEIMERS-DISEASE

INVESTIGATION OF THE NUCLEOLAR ORGANIZER REGIONS IN ALZHEIMERS-DISEASE

Author Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Smith, MDC Google Scholar
Kormann-Bortolotto, Maria Helena Autor UNIFESP Google Scholar
Toniolo Neto, João Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The Ag-stained nucleolus organizer regions and the satellite association (SA) were studied in peripheral lymphocyte cultures derived from 10 patients with Alzheimer's disease (AD), 10 elderly controls and 10 young controls. Our results showed a significant lower frequency of Ag staining and SA in relation to the chromosome pair 21 in the AD patient group when compared with the elderly and young control groups. These results point to a reduction in the activity of ribosomal genes in the AD patient group.
Keywords ALZHEIMERS DISEASE
CHROMOSOME 21
NUCLEOLUS ORGANIZER REGIONS
RIBOSOMAL GENES
SATELLITE ASSOCIATION
Language English
Date 1994-01-01
Published in Gerontology. Basel: Karger, v. 40, n. 1, p. 13-17, 1994.
ISSN 0304-324X (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 13-17
Origin https://doi.org/10.1159/000213569
Access rights Closed access
Type Article
Web of Science ID WOS:A1994NG32200003
URI http://repositorio.unifesp.br/11600/43728

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