ALZHEIMERS-DISEASE AND AGING - A CHROMOSOMAL APPROACH

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dc.contributor.author Kormann-Bortolotto, Maria Helena [UNIFESP]
dc.contributor.author Smith, MDC
dc.contributor.author Toniolo Neto, João [UNIFESP]
dc.date.accessioned 2018-06-15T17:30:21Z
dc.date.available 2018-06-15T17:30:21Z
dc.date.issued 1993-01-01
dc.identifier https://doi.org/10.1159/000213508
dc.identifier.citation Gerontology. Basel: Karger, v. 39, n. 1, p. 1-6, 1993.
dc.identifier.issn 0304-324X
dc.identifier.uri http://repositorio.unifesp.br/11600/43727
dc.description.abstract Alzheimer's disease (AD) is the most common type of dementia in elderly people. Interrelations between AD and senescence have been the subject of many studies. Some researchers have suggested that chromosomal alterations may be involved in the etiology or pathogenesis of AD. We present cytogenetic findings in patients with Alzheimer's disease, normal elderly controls and young controls. Aneuploidy, premature centromere division, polyploidy and C-anaphase, were analysed and the results suggest that the cytogenetic alterations observed are inherent to the cellular ageing process and not specifically related to Alzheimer's disease. en
dc.format.extent 1-6
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Gerontology
dc.rights Acesso restrito
dc.subject ALZHEIMERS DISEASE en
dc.subject AGING en
dc.subject CHROMOSOMAL ABNORMALITIES en
dc.subject CYTOGENETICS en
dc.title ALZHEIMERS-DISEASE AND AGING - A CHROMOSOMAL APPROACH en
dc.type Artigo
dc.rights.license http://www.karger.com/Services/RightsPermissions
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED SCH,DEPT MORFOL,DISCIPLINA GENET,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliation ESCOLA PAULISTA MED SCH,SETOR GERIATR & GERONTOL,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,DEPT MORFOL,DISCIPLINA GENET,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,SETOR GERIATR & GERONTOL,BR-04023 SAO PAULO,BRAZIL
dc.identifier.doi 10.1159/000213508
dc.description.source Web of Science
dc.identifier.wos WOS:A1993KN39500001



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