ALZHEIMERS-DISEASE AND AGING - A CHROMOSOMAL APPROACH

ALZHEIMERS-DISEASE AND AGING - A CHROMOSOMAL APPROACH

Author Kormann-Bortolotto, Maria Helena Autor UNIFESP Google Scholar
Smith, MDC Google Scholar
Toniolo Neto, João Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Alzheimer's disease (AD) is the most common type of dementia in elderly people. Interrelations between AD and senescence have been the subject of many studies. Some researchers have suggested that chromosomal alterations may be involved in the etiology or pathogenesis of AD. We present cytogenetic findings in patients with Alzheimer's disease, normal elderly controls and young controls. Aneuploidy, premature centromere division, polyploidy and C-anaphase, were analysed and the results suggest that the cytogenetic alterations observed are inherent to the cellular ageing process and not specifically related to Alzheimer's disease.
Keywords ALZHEIMERS DISEASE
AGING
CHROMOSOMAL ABNORMALITIES
CYTOGENETICS
Language English
Date 1993-01-01
Published in Gerontology. Basel: Karger, v. 39, n. 1, p. 1-6, 1993.
ISSN 0304-324X (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 1-6
Origin https://doi.org/10.1159/000213508
Access rights Closed access
Type Article
Web of Science ID WOS:A1993KN39500001
URI http://repositorio.unifesp.br/11600/43727

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