Protective effect of aminoguanidine in a murine model of pulmonary fibrosis induced by bleomycin

Protective effect of aminoguanidine in a murine model of pulmonary fibrosis induced by bleomycin

Author Rezende, Mario Cesar de Autor UNIFESP Google Scholar
Martinez, José Antônio Baddini Autor UNIFESP Google Scholar
Capelozzi, Vera Luiza Google Scholar
Simões, Manuel de Jesus Autor UNIFESP Google Scholar
Beppu, Osvaldo Shigueomi Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Aminoguanidine is a drug known for more than a century, which has been attracting increasing interest in recent years due to the discovery of new pharmacological properties. This study investigated the effects of aminoguanidine on the fibrotic response induced by intratracheal administration of bleomycin to rats. Three groups of animals were studied: Group A (n = 19) corresponded to the control group. Group B (n = 20) received 10 IU/kg bleomycin intratracheal, and Group C (n = 12) received the same amount of bleomycin as Group B Followed by 50 mg/kg/day aminoguanidine bicarbonate for 4 weeks. Aminoguanidine led to significant reductions in total hydroxyproline content of the longs in Group C compared to Group B (Group A: 1.83 +/- 0.14 mg x Group B: 3.46 +/- 0.36 mg x Group C: 2.09 +/- 22 mg). Morphometric collagen studies carried out on histological sections stained with Sirius red F3BA showed that aminoguanidine promoted a significant reduction of the area occupied by collagen in the axial and septal zones of the lungs (Axial region = Group A: 4.29 +/- 1.31% x Group B: 19.30 +/- 4.86% x Group C: 8.52 +/- 1.96%; Septal region = Group A: 0.15 +/- 0.06% x Group B: 0.61 +/- 0.21% x Group C: 0.15 +/- 0.06%). These results suggest that aminoguanidine is a potential therapeutic agent for the treatment and prevention of pulmonary fibrosis which is associated with different clinical conditions. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
Keywords aminoguanidine
pulmonary fibrosis
Language English
Date 2000-11-01
Published in Fundamental & Clinical Pharmacology. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 14, n. 6, p. 561-567, 2000.
ISSN 0767-3981 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 561-567
Access rights Closed access
Type Article
Web of Science ID WOS:000166516000005

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