SERUM LEVELS OF ANDROSTANEDIOL GLUCURONIDE, TOTAL TESTOSTERONE, AND FREE TESTOSTERONE IN HIRSUTE WOMEN

SERUM LEVELS OF ANDROSTANEDIOL GLUCURONIDE, TOTAL TESTOSTERONE, AND FREE TESTOSTERONE IN HIRSUTE WOMEN

Autor Khoury, Marcos Yorghi Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Pardini, Dolores Perovano Autor UNIFESP Google Scholar
Vieira, Jose Gilberto Henriques Autor UNIFESP Google Scholar
De Lima, Geraldo Rodrigues Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To determine the serum levels of androstanediol glucuronide (3 alpha-diol G), total T, and free T in hirsute and nonhirsute women.Design: Controlled clinical study.Patients: Hirsute women with oligomenorrhea, hirsute women with regular ovulatory cycles, and nonhirsute women with regular cycles were selected.Main Outcome Measure: Serum levels of 3 alpha-diol G, total T, and free T were measured in 8 hirsute with oligomenorrhea and 11 hirsute women with regular ovulatory cycles and compared with 20 nonhirsute women with regular cycles (control group). Serum 3 alpha-diol G was also measured during the follicular, periovulatory, and luteal phases in hirsute women with regular cycles.Results: Serum levels of 3 alpha-diol G did not change during the menstrual cycle, in addition we observed that there was no difference between the levels of 3 alpha-diol G, total T, and free T in hirsute women with regular cycles when compared with normal women. These three serum androgens were elevated only in the hirsute women with oligomenorrhea. Besides, there was better correlation between total T and free T (r = 0.81) than total T and 3 alpha-diol G (r = 0.49) or free T and 3 alpha-diol G (r = 0.66).Conclusion: The findings suggest that serum 3 alpha-diol G does not provide additional benefit as a marker of hirsutism than serum total or free T.
Assunto ANDROSTANEDIOL GLUCURONIDE
TESTOSTERONE
HIRSUTISM
Idioma Inglês
Data 1994-07-01
Publicado em Fertility And Sterility. Birmingham: Amer Soc Reproductive Medicine, v. 62, n. 1, p. 76-80, 1994.
ISSN 0015-0282 (Sherpa/Romeo, fator de impacto)
Editor Amer Soc Reproductive Medicine
Extensão 76-80
Fonte http://www.fertstert.org/article/S0015-0282(16)56819-8/pdf
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1994NT07200012
URI http://repositorio.unifesp.br/11600/43682

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