Expression of p53 protein in the endometrial polyp in postmenopausal women

Expression of p53 protein in the endometrial polyp in postmenopausal women

Author Albuquerque Neto, Luiz Cavalcanti de Autor UNIFESP Google Scholar
Soares, Jose Maria Autor UNIFESP Google Scholar
Giusa-Chiferi, Maria Gabriela Autor UNIFESP Google Scholar
Goncalves, Wagner Jose Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Objective: To evaluate p53 protein expression in the endometrial polyp and compare with adenocarcinoma and atrophic endometrium of postmenopausal women. Materials and Methods: Ninety-eight postmenopausal women were included in this study and divided into three groups related to histopathologic diagnosis: Group A - endometrial adenocarcinoma (n = 40), Group B - endometrial polyp (n = 38), and Group C - endometrial atrophy (n = 20). The length of this study was from 1990 to 2004. The endometrial samples were collected from hysteroscopic biopsy or surgery then processed for histopathologic routine. One thousand cells of each histological section were evaluated for immunohistochemical analysis using p53 antibodies. The ANOVA test was performed for the statistical analysis. Results: The expression of p53 in adenocarcinoma samples was the highest. The expression of polyp was positive when associated to hyperplasia without atypia. All samples of atrophic endometrial were negative. Conclusions: The present data suggested that presence of hyperplasia in the endometrial polyp is factor to increase the expression of p53.
Keywords P53
Endometrial polyp
Postmenopause
Women
Adenocarcinoma
Language English
Date 2013-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 34, n. 6, p. 509-512, 2013.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 509-512
Origin http://www.irog.net/download/?magazine=116
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000341555600001
URI http://repositorio.unifesp.br/11600/43609

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