Fas/CD95 promoter polymorphism gene and its relationship with cervical carcinoma

Fas/CD95 promoter polymorphism gene and its relationship with cervical carcinoma

Author Zucchi, Flavio Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Ribalta, Julisa Chamorro Lascasas Autor UNIFESP Google Scholar
Nogueira-de-Souza, Naiara Corrêa Autor UNIFESP Google Scholar
Speck, Neila Maria de Góis Autor UNIFESP Google Scholar
Girao, M. J. B. C. Autor UNIFESP Google Scholar
Brenna, S. M. F. Google Scholar
Syrjanen, K. J. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
City Univ
Leonor Mendes Barros Matern Hosp
Turku Univ Hosp
Abstract Objective: Apoptosis is an important fail-safe control in human papillomavirus (HPV)-associated carcinogenesis. We tested the hypothesis that the A/G polymorphism at -670 of Fas promoter is associated with an increased risk for cervical cancer, using a matched case-control setting. Methods: The material in this case-control study consisted of 91 patients with cervical carcinoma and 176 population-based control subjects, recruited between 2002 and 2004 all the ethnic Brazilian women had histologically confirmed cervical carcinoma. Control Subjects were age-matched; healthy women who were selected following a negative cervical cytology and normal colposcopy. Fas genotyping was performed using a PCR-RFLP technique. Results: No significant difference existed in the distribution of the Fas polymorphisms (wild, heterozygous. mutant) between the cases and controls. The heterozygous (OR: 4.85, 95% CI: 1.1-22.6) genotypes among the younger (< 48 yrs) cancer patients were almost 5-fold increased, as compared with the wild type. No such increase was observed among the patients older than 48 years. Conclusions: Our data Suggest that 670A/G polymorphism in the promoter region of the death receptor Fas is associated with an increased risk of cervical cancer among Brazilian women under 48 years. The mechanisms would be the inhibition of apoptosis by Fas -670G allele-mediated down-regulation of Fas transcription..
Keywords Fas
Polymorphism
Apoptosis
Human papillomavirus
Cervical cancer
Risk factor
Language English
Date 2009-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 30, n. 2, p. 142-144, 2009.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 142-144
Access rights Closed access
Type Article
Web of Science ID WOS:000264588300005
URI http://repositorio.unifesp.br/11600/43601

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