Polymorphisms of p53, GSTM1 and GSTT1, and HPV in uterine cervix adenocarcinoma

Polymorphisms of p53, GSTM1 and GSTT1, and HPV in uterine cervix adenocarcinoma

Author Carvalho, Carmen Regina Nogueira de Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Pereira, J. S. Autor UNIFESP Google Scholar
Nogueira-de-Souza, Naiara Corrêa Autor UNIFESP Google Scholar
Focchi, Gustavo Rubino de Azevedo Autor UNIFESP Google Scholar
Ribalta, Julisa Chamorro Lascasas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To analyze the participation of glutathione-S-transferase (GST) M I and T I polymorphisms associated protein p53 polymorphism at codon 72 and in the presence of HPV in the carcinogenesis of uterine cervix adenocarcinoma. Methods: Forty-three samples of uterine cervix adenocarcinoma were studied and 86 samples of endocervical cells of women without tumors formed the control group. The presence of HPV was determined in order to genotype the isoforms of p53 at codon 72, GSTM1. GSTM1*0, GSTT1 and GSTT1*0 which were evaluated by the PCR method. Results: HPV was present in 97.67% of the adenocarcinoma cases and in 31.40% of the control group. Statistical analysis showed differences (p = 0.001) and an OR of 113.3 (CI 95%: 13.67-947.14). GSTT1 and GSTT1*0 analysis showed a significant difference between the groups (p = 0.001) with an OR of 4.58 (CI 95%: 2.041-10.28) (p < 0.001) for the presence of GSTT1*0. When it was associated with HPV OR was 6.6 (CI 95%: 0.04-0.50). Analyses of p53 and GSTM1 and GSTM1*0 either alone or associated with HPV were not significant. Conclusion: The presence of GSTT1*0 increased the risk for uterine cervix adenocarcinoma development while the allele GSTT1 had it protective action. The other isoforms did not appear to participate in the carcinogenesis of uterine cervix adenocarcinoma.
Keywords p53
GSTM1
GSTT1
HPV
Adenocarcinoma
Language English
Date 2008-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 6, p. 590-593, 2008.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 590-593
Origin http://www.irog.net/download/?magazine=102
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000260301200006
URI http://repositorio.unifesp.br/11600/43600

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