Bcl-2 oncogene expression in estrogen receptor-positive and negative breast carcinoma

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dc.contributor.author Santos, L. G. dos
dc.contributor.author Lopes-Costa, P. V.
dc.contributor.author Santos, A. R. dos
dc.contributor.author Facina, Gil [UNIFESP]
dc.contributor.author Silva, B. B. da
dc.date.accessioned 2018-06-15T17:22:25Z
dc.date.available 2018-06-15T17:22:25Z
dc.date.issued 2008-01-01
dc.identifier http://www.irog.net/download/?magazine=91
dc.identifier.citation European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 5, p. 459-461, 2008.
dc.identifier.issn 0392-2936
dc.identifier.uri http://repositorio.unifesp.br/11600/43598
dc.description.abstract Purpose: The aim of this study was to evaluate Bcl-2 oncogene expression in estrogen receptor (ER)-positive and negative breast carcinomas. Methods: A Study involving 72 cases of infiltrating ductal carcinoma of the breast in postmenopausal women divided into two groups: Group A (ER positive, n = 37) and Group B (ER negative, n = 35). Immunohistochemical analysis of bcl-2 expression was carried out semiquantitatively based on the percentage of stained tumoral cells and the intensity of staining. The chi-square test was used in the statistical analysis of the data and significance was established at p < 0.05. Results: Bcl-2 oncogene expression was statistically greater in tumors of Group A (59.5%) compared to those of Group B (8.6%), (p < 0.001). Conclusion: Bcl-2 had a significantly greater expression in the ER-positive breast tumors compared to ER-negative tumors. en
dc.format.extent 459-461
dc.language.iso eng
dc.publisher I R O G Canada, Inc
dc.relation.ispartof European Journal Of Gynaecological Oncology
dc.rights Acesso aberto
dc.subject breast en
dc.subject cancer en
dc.subject apoptosis en
dc.subject estrogen receptor en
dc.subject bcl-2 en
dc.title Bcl-2 oncogene expression in estrogen receptor-positive and negative breast carcinoma en
dc.type Artigo
dc.contributor.institution Univ Fed Piaui
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Piaui, Dept Pathol, Teresina, Piaui, Brazil
dc.description.affiliation Univ Fed Piaui, Dept Gynecol, Teresina, Piaui, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000259328800008



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