Bcl-2 oncogene expression in estrogen receptor-positive and negative breast carcinoma

Bcl-2 oncogene expression in estrogen receptor-positive and negative breast carcinoma

Author Santos, L. G. dos Google Scholar
Lopes-Costa, P. V. Google Scholar
Santos, A. R. dos Google Scholar
Facina, Gil Autor UNIFESP Google Scholar
Silva, B. B. da Google Scholar
Institution Univ Fed Piaui
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: The aim of this study was to evaluate Bcl-2 oncogene expression in estrogen receptor (ER)-positive and negative breast carcinomas. Methods: A Study involving 72 cases of infiltrating ductal carcinoma of the breast in postmenopausal women divided into two groups: Group A (ER positive, n = 37) and Group B (ER negative, n = 35). Immunohistochemical analysis of bcl-2 expression was carried out semiquantitatively based on the percentage of stained tumoral cells and the intensity of staining. The chi-square test was used in the statistical analysis of the data and significance was established at p < 0.05. Results: Bcl-2 oncogene expression was statistically greater in tumors of Group A (59.5%) compared to those of Group B (8.6%), (p < 0.001). Conclusion: Bcl-2 had a significantly greater expression in the ER-positive breast tumors compared to ER-negative tumors.
Keywords breast
cancer
apoptosis
estrogen receptor
bcl-2
Language English
Date 2008-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 5, p. 459-461, 2008.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 459-461
Origin http://www.irog.net/download/?magazine=91
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000259328800008
URI http://repositorio.unifesp.br/11600/43598

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