Differential gene expression profile reveals overexpression of MAP3K8 in invasive endometrioid carcinoma

Differential gene expression profile reveals overexpression of MAP3K8 in invasive endometrioid carcinoma

Author Alves, C. Aparecida Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Villanova, Fabiola Elizabeth Autor UNIFESP Google Scholar
Nicolau, Sergio Mancini Autor UNIFESP Google Scholar
Custodio, M. A. Google Scholar
Bortoletto, C. Google Scholar
Goncalves, Wagner Jose Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Gene microarray technology is highly effective in screening for differential gene expression and has hence become a popular tool in the molecular investigation of cancer. In the present study, cDNA microarrays containing 2,000 different genes were used to analyze gene expression profiles in ten human postmenopausal endometrioid-paired carcinoma specimens versus corresponding adjacent normal tissue to identify differentially expressed genes. In our study several genes were found differentially expressed. One of them was the MAP3K8, a gene that has never been described to be overexpressed in this kind of malignancy. To validate the differential expression of this gene as well as the membrane array, we performed semiquantitative reverse transcription-PCR analysis. MAP3K8 was found overexpressed in 30% of the endometrial carcinoma samples. To the best of our knowledge this is the first report showing the MAP3K8 oncogene linked to human endometrial carcinoma suggesting that it may be another molecule involved in human endometrial cancer.
Keywords cDNA array
endometrial carcinoma
Language English
Date 2006-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 27, n. 6, p. 589-593, 2006.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 589-593
Origin http://www.irog.net/download/?magazine=100
Access rights Closed access
Type Article
Web of Science ID WOS:000242977700009
URI http://repositorio.unifesp.br/11600/43596

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